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Chitosan-functionalized metal organic framework materials as well as preparation method and application thereof

A metal-organic framework and chitosan technology, which is applied in the fields of material chemistry and biomedicine, can solve the problems of no clear conclusion and instability of the toxicity of the organism and the degree of biocompatibility, and achieve easy control and realization of the preparation conditions. Increased stability and improved biocompatibility

Active Publication Date: 2014-07-16
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are two key factors restricting the development of metal-organic frameworks in the field of drug delivery: first, most metal-organic frameworks are unstable under physiological conditions; second, the toxicity and biocompatibility of metal-organic frameworks to organisms There is no definite conclusion

Method used

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  • Chitosan-functionalized metal organic framework materials as well as preparation method and application thereof
  • Chitosan-functionalized metal organic framework materials as well as preparation method and application thereof
  • Chitosan-functionalized metal organic framework materials as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The nano-sized metal-organic framework material will be synthesized and loaded with anti-tumor drug 5-fluorouracil. The metal-organic framework will be modified with chitosan to make it have better biocompatibility and stability, and then the drug molecule folinic acid will be loaded. It is better used in the treatment of tumors. Select 4,4',4''-tricarboxytriphenylamine as the organic ligand, use crystal engineering theory and chemical self-assembly technology and metal element Zn as the node to construct a series of metal-organic frameworks of different shapes, and modify 5-fluorouracil to metal-organic framework. The carboxyl group on the surface of the metal-organic framework can be activated by EDC to connect to the chitosan with amino groups, and the drug molecule folinic acid is loaded on the chitosan. The specific steps are as follows:

[0039] (1) Preparation of nano-sized metal-organic frameworks with zinc as nodes and 4,4',4''-tricarboxytriphenylamine as orga...

Embodiment 2

[0051] When drugs are used to treat eye diseases, the eyes will produce a lot of tears after being stimulated, and the drugs will be diluted and cleared, making the treatment effect relatively poor. The nano-sized metal organic framework modified by chitosan is used as the drug carrier, due to the chitosan nano Microparticles have the characteristic of attaching to the surface of the mucous membrane of the organism, so the targeting of nano-sized metal-organic frameworks can be improved, and the drugs loaded on them can stay in the eye for a long time, which is beneficial to the treatment of eye diseases. In this example, chitosan-modified nano-sized metal-organic frameworks are simultaneously loaded with drugs timolol maleate and betaxolol for the treatment of primary glaucoma, which can be used for the treatment of primary glaucoma. Specific steps are as follows:

[0052] (1) Ultrasonic preparation of nano-sized metal-organic frameworks with copper as nodes and triphenylamin...

Embodiment 3

[0061] For certain bacterial infections, the combination of antibacterial drugs can effectively kill bacteria and relieve disease symptoms. In this example, for Proteus infection, the synthesized chitosan modified chitosan modified metal Cu is used as the node, and the nanometer-sized metal-organic framework with terephthalic acid as the ligand is simultaneously loaded with antibacterial drugs ampicillin and gentamicin It can be used to treat Proteus infection. Specific steps are as follows:

[0062] (1): Nano-sized metal-organic frameworks with metal Cu as nodes and terephthalic acid as ligands prepared by microwave method:

[0063] Take a mixture of teredibenzoic acid (0.3mmol), copper nitrate (1mmol), 0.5g CATB, 20ml of N,N'-dimethylformamide, ethanol and deionized water in a volume ratio of 3:1:0.3 Put the solution into a beaker, stir for 15 minutes, heat the mixed system for 1 minute, stop for 2 minutes, and then heat for 3 minutes. The microwave heating power is 1000W....

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Abstract

The invention discloses chitosan-functionalized metal organic framework materials. The chitosan-functionalized metal organic framework materials comprise at least one metal ion and an organic ligand. A preparation method of the chitosan-functionalized metal organic framework materials comprises the following step of: carrying out hydrothermal reaction on the metal ion and the organic ligand in a certain proportion at high temperature in a reaction kettle or reacting by adopting a microwave process, an ultrasonic process, and the like by taking a surfactant as a template to synthesize the metal organic framework materials in different shapes, and modifying the metal organic framework materials by a biocompatible material chitosan and a derivative thereof, and the like, to functionalize the organic framework materials. In a process of synthesizing nano-scale metal organic frameworks and modifying by using chitosan and the derivative thereof, different drug molecules can be loaded to the internal frameworks of the metal organic frames and external chitosan macromolecular structures. The chitosan-functionalized nano-scale metal organic framework materials disclosed by the invention can be applied to targeted transportation of various drugs and controlled release of drugs in a living body.

Description

technical field [0001] The invention relates to a chitosan functionalized metal organic framework material and a preparation method and application thereof, belonging to the fields of material chemistry and biomedicine. Background technique [0002] In the field of biomedicine, the application of nanomaterials in drug delivery systems has great advantages. First of all, nanomaterials have a large specific surface area and can load more drug molecules; secondly, nanomaterials can carry drug molecules to prevent drug degradation and diffusion during transportation, and reduce drug interaction while achieving targeted drug delivery. Toxicity to other parts of the body; moreover, nanomaterials loaded with drug molecules enter cells through mechanisms such as endocytosis, which can increase the permeability of drugs to biomembranes, which is conducive to drug absorption and intracellular drug efficacy. Therefore, a variety of organic or inorganic nanomaterials have been applied ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/02
Inventor 王宗花闫志勇赵凯夏建飞张菲菲夏霖迟德玲夏临华李延辉夏延致
Owner QINGDAO UNIV
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