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Preparation method and applications of bupleurum tenue capsule

A technology of bupleurum and capsules, which is applied in the direction of capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve the problems of large dosage for patients, rough process, and many impurities, and achieve the effect of reducing the dosage

Active Publication Date: 2014-08-13
云南云龙制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Xiaochaihu Capsules. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the This product is used clinically

Method used

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  • Preparation method and applications of bupleurum tenue capsule
  • Preparation method and applications of bupleurum tenue capsule

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Get Bupleurum 445g, ginger Pinellia 222g, Scutellaria baicalensis 167g, Codonopsis 167g, Radix Glycyrrhizae 167g, Ginger 167g, Jujube 167g and join in the CO2 supercritical extractor, ethanol is used as entrainer, and the volume percentage of entrainer accounting for the total extraction solvent is 4%, extraction pressure 15MPa, temperature 30°C, CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained, which is concentrated into a thick paste with a relative density of 1.20 at 80°C. Starch is added, mixed, dried, ground into fine particles, dried, and made into 1000 capsules, ready to serve.

Embodiment 2

[0031] Take 445g of Bupleurum, 222g of ginger Pinellia, 167g of Scutellaria baicalensis, 167g of Codonopsis 167g, 167g of licorice, 167g of ginger, and 167g of jujube into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained, which is concentrated into a thick paste with a relative density of 1.25 at 80°C, added with starch, mixed, dried, finely ground, made into granules, dried, and made into 1000 capsules, ready to serve.

Embodiment 3

[0033] Take 445g of Bupleurum, 222g of ginger Pinellia, 167g of Scutellaria baicalensis, 167g of Codonopsis 167g, 167g of licorice, 167g of ginger, and 167g of jujube into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 5%, the extraction pressure is 20MPa, the temperature is 40°C, and CO 2The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained, which is concentrated into a thick paste with a relative density of 1.22 at 80°C. Starch is added, mixed, dried, ground into fine particles, dried, and made into 1000 capsules, ready to serve.

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Abstract

The invention provides a preparation method of a bupleurum tenue capsule. The bupleurum tenue capsule is prepared from the following active pharmaceutical ingredients: 445g of bupleurum tenue, 222g of pinellia ternata stir-baked with ginger juice, 167g of scutellaria baicalensis, 167g of codonopsis pilosula, 167g of liquorice, 167g of fresh ginger and 167g of Chinese dates. The bupleurum tenue capsule is prepared by means of supercritical extraction, so that the content of active ingredients is increased greatly and the dosage is reduced. The invention also provides the applications of the bupleurum tenue capsule in preparing medicines for inhibiting proliferation of human histocyte lymphoma U937 cells and medicines for increasing red blood cells.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Xiaochaihu capsules. Background technique [0002] Xiaochaihu Capsules are recorded in the ministerial standard, the prescription is Bupleurum 445g, Ginger Pinellia 222g, Scutellaria baicalensis 167g, Codonopsis 167g, Licorice 167g, Ginger 167g, Jujube 167g, the above seven flavors, Codonopsis 45g and licorice are crushed into fine powder, take 96g for later use, the remaining fine powder and the remaining Codonopsis pilosula, Bupleurum baicalensis, Scutellaria baicalensis, and jujube are decocted twice, each time for 1.5 hours, and the filtrate is combined, filtered, and the filtrate is concentrated to a relative density of 1.0-1.2 (80°C); Jiang Pinellia, Ginger Zhaoliu extract and the percolation method under the item of extract (Chinese Pharmacopoeia 2010, Appendix IO), use 70% ethanol as a solvent, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/48A61P35/00A61P7/00
Inventor 杨建云
Owner 云南云龙制药股份有限公司
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