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Application of aristolochic acid in preparation of drugs treating rheumatoid arthritis

A kind of aristolochic acid, rheumatoid technology, applied in the field of medicine, can solve the problem that there is no topical medicine of aristolochic acid

Inactive Publication Date: 2014-08-20
孔徐生 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the investigation, there is no report of topical application of aristolochic acid or drugs containing aristolochic acid

Method used

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  • Application of aristolochic acid in preparation of drugs treating rheumatoid arthritis
  • Application of aristolochic acid in preparation of drugs treating rheumatoid arthritis
  • Application of aristolochic acid in preparation of drugs treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Take 10,000 grams of Asarum medicinal material, add 30,000 grams of methanol to reflux extraction twice, each time for 3 hours, filter, combine the two filtrates, evaporate the filtrate, recover methanol, dissolve the residue with 1% hydrochloric acid aqueous solution, add 2% sodium carbonate aqueous solution When the pH reached 8.5, an appropriate amount of dichloromethane was added for extraction three times, the aqueous phase was discarded, the dichloromethane extracts were combined, evaporated to dryness, and the dichloromethane was recovered to obtain 0.508 g of aristolochic acid.

Embodiment 2

[0049] Take 2g of Carbomer-971, add appropriate amount of distilled water to soak, stir to make it swell into a uniform paste, then add ethylparaben, add triethanolamine dropwise, and adjust the pH to 7.5; take 5g of aristolochic acid and add the swollen carbomer Add 15.1g of laurocaprazine again, add distilled water to 80g, and stir until transparent to obtain the gel of the present invention.

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Abstract

The invention provides application of aristolochic acid in preparation of immunosuppressive drugs, especially application in drugs treating rheumatoid arthritis. The aristolochic acid gel provided by the invention can effectively inhibit rheumatoid arthritis and has no renal toxic reaction, thus providing a new choice for clinical treatment of rheumatoid arthritis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of aristolochic acid in medicine for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (rheumatoid arthritis) is a chronic systemic disease mainly characterized by non-suppurative inflammation of joints and soft tissues around the joints. Its course of disease is repeated for a long time, and the disability rate is high. With chronic, symmetrical, polysynovitis arthritis and extra-articular lesions as the main clinical manifestations, it belongs to autoimmune inflammatory disease. The disease is distributed globally, and the prevalence rate in my country is 0.32%-0.36%. It is one of the main causes of labor loss and disability in my country. Once the disease occurs, it will seriously affect the quality of life of patients. The current treatment methods mainly use hormones and anti-metabolic drugs for anti-inflammation and immunotherapy, but the ad...

Claims

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Application Information

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IPC IPC(8): A61K31/36A61P19/02A61P29/00A61P37/06
Inventor 孔徐生刘洋孔翔
Owner 孔徐生
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