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A vegetable soft capsule

A soft capsule, plant-based technology, applied in the field of pharmaceutical preparation, can solve the problems of not being able to use pig products, limit the use of gelatin, and low production efficiency, and achieve the effects of shortening the disintegration time limit, being friendly to the production environment, and good in use safety

Active Publication Date: 2016-02-03
QINGDAO DOUBLE WHALE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, domestic soft capsules are mainly produced with gelatin as raw material. Gelatin is an excellent thermally reversible gelling agent. However, soft capsules made of gelatin usually have delayed disintegration, which is mainly due to the The gelatin in the gelatin is affected by low-molecular-weight aldehydes and the oxidation process, resulting in a cross-linking reaction that causes the aging of the gelatin. In addition, because gelatin is mostly extracted from the skin and bones of pigs and cattle, a considerable number of people in the world cannot use it. Pig products, eg: Hebrew, Muslim, Vegan, and gelatin products are not declared of their animal origin, thus limiting the use of gelatin
In recent years, mad cow disease has spread around the world, and gelatin has potential safety hazards to a certain extent. These have prompted people to study plant-based soft capsules to replace traditional gelatin capsules. However, the shells of existing plant-based soft capsules mostly use xanthan gum, karaage, etc. Gum and gum arabic, etc., these plant gums dissolve slowly in water, tend to form clusters to delay the dissolution rate, and have low production efficiency, which is not conducive to the actual operation of large-scale production. It is a new type of galactomannan gum discovered in the 1970s. It is now used as a food additive in food. Since the research on squash gum in China started relatively late, there are currently few applications of squash gum in the field of vegetable capsules. According to the research report, it was found that the proper proportion of safflower gum and other ingredients has good film-forming properties, and it can be used for plant capsules. Moreover, safflower gum has a great affinity for water and can be dispersed in In cold water, it absorbs many times its own volume of water to swell and produce hydration, forming a high-viscosity glue. Compared with other plant gums such as xanthan gum and carrageenan, squash gum dissolves quickly and easily in water. There will be no phenomenon that the clusters are not easy to dissolve, and it is more conducive to large-scale production operations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The preparation process of this embodiment is as follows: first pump 245kg of purified water and 22.5kg of glycerin into the sol tank, stir evenly, then add 16.5kg of squash gum, 98kg of pregelatinized starch and 15kg of sodium alginate; Add 27.5g of red, 2.4kg of titanium dioxide and 60g of Tween 80 into 5kg of purified water respectively, disperse evenly, and pump them into the sol tank, raise the temperature to 70°C-85°C, stir and keep warm until the safflower gum is completely dissolved, and then evacuate to no Air bubbles to get glue, then put the glue into the insulation barrel through a 100-mesh filter, adopt the conventional pressing method, control the temperature of the glue box at 60°C to 70°C, and the temperature of the spray body at 45°C to 55°C, and press it into Wet and soft capsules, after the wet and soft capsules are finalized in a rolling cage, placed in a temperature of 25°C to 33°C and a relative humidity of 30% to 60%, after drying, a soft capsule p...

Embodiment 2

[0012] The preparation process of this embodiment is as follows: first pump 270 kg of purified water and 58 kg of glycerin into the sol tank, start stirring, and then add 45 kg of squash gum, 33 kg of pregelatinized starch, 5 kg of sodium alginate and 7.5 kg of pullulan kg; add 30g of sodium dodecylsulfonate into 5kg of purified water, dissolve it and pump it into a sol tank, raise the temperature to 70°C-85°C, stir and keep warm until the seaweed glue is completely dissolved, then vacuum until there are no bubbles, and the glue Put it into the heat preservation barrel through a 100-mesh filter, use the pressing method, control the temperature of the plastic box at 60°C to 70°C, and the temperature of the spray body at 45°C to 55°C, and press it into soft and soft capsules, and make the soft and soft capsules in the rolling cage After setting in the middle, put it in the temperature of 25 ℃~33 ℃, dry under the condition of relative humidity 30%~60%, obtain the soft capsule prod...

Embodiment 3

[0014] The preparation process of this example is as follows: pump 200kg of purified water, 75kg of glycerin, and 5.5kg of sorbitol into the sol tank, start stirring, add 22kg of squash gum, 32.5kg of pregelatinized starch, 7.5kg of sodium alginate and common Add 6kg of Lulan polysaccharide, then add 50g of Tween 80 into 5kg of purified water, disperse evenly, pump it into the sol tank, raise the temperature to 70℃~85℃, stir and keep warm until completely dissolved, vacuumize until there are no bubbles, and the glue is passed through 100 mesh Put the filter into the heat preservation barrel, adopt the conventional pressing method, control the temperature of the plastic box at 60°C to 70°C, and the temperature of the spray body at 45°C to 55°C, press it into wet soft capsules, and make the wet soft capsules finalize in the rolling cage Finally, it is placed in a temperature of 25°C to 33°C and dried under the conditions of relative humidity of 30% to 60%, so as to obtain a soft ...

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Abstract

The invention belongs to the technical field of medicine preparation and relates to a vegetative soft capsule made of vegetative sesbania gum as principle raw materials and other auxiliary materials added into the principle raw materials. Main ingredients of the vegetative soft capsule comprise the sesbania gum, pregelatinized starch, surface active agents and plasticizer. Firstly, purified water and the plasticizer are pumped into an aerosol tank and mixed and then the sesbania gum, the pregelatinized starch and film-forming agents are added; secondly, color agents and the surface active agents are added into a small amount of purified water reserved in advance and are also pumped into the aerosol tank after being dispersed evenly; thirdly, mixtures are heated and stirred until the sesbania gum is completely dissolved; fourthly, vacuum pumping is conducted until no bubbles exist; finally, the vegetative soft capsule is made and obtained in a conventional pressing method or a dropping method. The vegetative soft capsule has good film-forming properties and good toughness and elasticity, the disintegration time of the vegetative soft capsule can be shortened, the vegetative soft capsule is not prone to adhesion, capable of avoiding gum powder huddling and indissolvableness, simple in overall preparation process, safe, reliable, capable of saving raw materials and energy, reliable in product quality, good in use safety and friendly to production environment.

Description

Technical field: [0001] The invention belongs to the technical field of medicine preparation, and relates to a process technology for preparing natural vegetable soft capsules, in particular to a vegetable soft capsule prepared by adding other supplementary materials from vegetable quince gum as the main raw material. Background technique: [0002] At present, domestic soft capsules are mainly produced with gelatin as raw material. Gelatin is an excellent thermally reversible gelling agent. However, soft capsules made of gelatin usually have delayed disintegration, which is mainly due to the The gelatin in the gelatin is affected by low-molecular-weight aldehydes and the oxidation process, resulting in a cross-linking reaction that causes the aging of the gelatin. In addition, because gelatin is mostly extracted from the skin and bones of pigs and cattle, a considerable number of people in the world cannot use it. Pig products, eg: Hebrew, Muslim, Vegetarian, and gelatin pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36
Inventor 耿仕霞倪志伟姜金晓冯淑蕾胡艳芬
Owner QINGDAO DOUBLE WHALE PHARMA
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