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Human Milk Oligosaccharides For Preventing Injury And/Or Promoting Healing Of The Gastrointestinal Tract

一种人乳寡糖、胃肠道的技术，应用在人乳寡糖领域，能够解决不存在天然肠修复功能、不足等问题

Inactive Publication Date: 2014-09-03
ABBOTT LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003]However not all individuals have sufficient expression of mucin-binding proteins to achieve prophylaxis and required intestinal repair which can lead to translocations, sepsis and increased risk of possible death
Furthermore, there are currently no commercially available nutritional compositions containing mucin-binding proteins such as trefoil factor 3 (TFF3), or the administration of additional components to increase expression of mucin-binding proteins to assist individuals with insufficient natural intestinal repair. known method

Method used

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  • Human Milk Oligosaccharides For Preventing Injury And/Or Promoting Healing Of The Gastrointestinal Tract
  • Human Milk Oligosaccharides For Preventing Injury And/Or Promoting Healing Of The Gastrointestinal Tract
  • Human Milk Oligosaccharides For Preventing Injury And/Or Promoting Healing Of The Gastrointestinal Tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0138] Examples 1-20 illustrate spray-dried nutritional powders of the present disclosure, the ingredients of which are listed in the table below. All ingredient amounts are listed in kg per 1000 kg batch of product unless otherwise specified.

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Embodiment 21-40

[0148] Examples 21-40 illustrate spray-dried nutritional powders of the present disclosure, the ingredients of which are listed in the table below. All ingredient amounts are listed in kg per 1000 kg batch of product unless otherwise specified.

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Embodiment 41-60

[0156] Examples 41-60 illustrate liquid emulsions of the present disclosure, the ingredients of which are listed in the table below. All ingredient amounts are listed in kg per 1000 kg batch of product unless otherwise specified.

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Abstract

Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to individuals including preterm infants, infants, toddlers, children, and adults for preventing injury and / or improving the healing of the gastrointestinal tract. Additional suitable methods of using the nutritional compositions including the human milk oligosaccharides are also disclosed.

Description

field of invention [0001] The present disclosure relates to the use of human milk oligosaccharides for preventing gastrointestinal injury and / or enhancing healing of an injured gastrointestinal tract in an individual. More specifically, the present disclosure relates to human milk fortifiers, formulas for preterm and term infants, pediatric formulas, follow-on formulas, and adult nutritionals that contain proteins that enhance the expression of various mucin-binding proteins, thereby improving the gastrointestinal tract of an individual Human milk oligosaccharides with preventive and repair functions. Background of the invention [0002] Individuals undergoing multiple therapies or suffering from multiple diseases and / or conditions are generally more susceptible than healthy individuals to intestinal mucosal (gastrointestinal) damage or an immunocompromised GI tract. Expression of mucin-binding or secreted proteins is an integral part of an individual's natural ability to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L1/30A61K31/702A61P1/00A23L33/00
CPCA23L1/3085A61K2035/115A61K35/747A61K35/745A23V2002/00A23L1/308A61K31/702A61K35/744A61K35/741A23L1/296A23L29/30A23V2200/32A23V2250/60A23L33/40A23L33/21A23L33/28A61P1/00
Inventor S.R.戴维斯J.周
Owner ABBOTT LAB INC
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