Method for preparing tianeptine sodium intermediate

A technology for tianuptine sodium and intermediates, which is applied in the field of preparation of pharmaceutical intermediates, can solve the problems of large waste water, serious pollution, and high energy consumption, and achieve the effects of less three wastes, no discharge of three wastes, and high purity
CN104031005AActive Publication Date: 2014-09-10山东诚汇双达药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
山东诚汇双达药业有限公司
Publication Date
2014-09-10

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Abstract

The invention discloses a method for preparing a tianeptine sodium intermediate 3-chloro-6-methyl dibenzo[c, f][1, 2] thiazepine-11-(6H)-ketone 5,5-dioxide. 4-chloro-2-(N-methyl-N-phenyl-sulfamoyl)-methyl benzoate is taken as a raw material for synthesizing the tianeptine sodium intermediate in one step. Compared with the prior art, the synthesis method is simple and convenient and has relatively good economic benefit.
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Description

technical field

[0001] The invention relates to the technical field of preparation of pharmaceutical intermediates, in particular to a preparation method of a tianuptine sodium intermediate. Background technique

[0002] Tianeptine is an antidepressant with significantly fewer adverse effects than tricyclic antidepressants. It has the following effects on animals: increasing the spontaneous activity of cone cells in the hippocampus, accelerating the recovery after functional inhibition, and accelerating the uptake of 5-hydroxytryptamine by neurons in the cerebral cortex and hippocampus. Tianeptine has the following action characteristics on the human body: the effect on mood disorders, in the two classifications of sedative and excitatory antidepressants, the effect of this drug is between the two. It has a significant effect on somatic symptoms, especially gastrointestinal symptoms related to anxiety and mood disorders. It has a relieving effect on the abnormal personalit...

Claims

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