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Method for screening active ingredients of traditional Chinese medicine

A technology of active ingredients and screening methods, which is applied in the field of screening active ingredients of traditional Chinese medicine, can solve problems such as unclear active ingredients, and achieve the effect of improving the success rate

Inactive Publication Date: 2014-09-10
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] In view of this, the present invention provides a method for screening active ingredients of traditional Chinese medicines, which solves the problem of unclear active ingredients of traditional Chinese medicine preparations in the prior art

Method used

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  • Method for screening active ingredients of traditional Chinese medicine

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Embodiment

[0059] Take Danhong injection as an example to screen cardiovascular active ingredients.

[0060] The method for screening active ingredients of traditional Chinese medicines in the embodiments of the present invention comprises the following steps:

[0061] First: provide alpha 1 - Adrenergic receptor subtype biochromatographic column

[0062] Step 2: Sample pretreatment

[0063] An appropriate amount of commercially available Danhong injection is diluted 50-100 times with ultrapure water, filtered with a 0.45 μm water filter membrane, and set aside. Appropriate amount of Danshen and safflower decoction pieces of traditional Chinese medicine were extracted with 8-15 times of ultrapure water for 3 times, each time for 30 minutes, filtered while hot, collected the subsequent filtrate, combined, cooled to room temperature, filtered with 0.45 μm water filter membrane, and set aside.

[0064] Step 3: Preliminary two-dimensional chromatographic screening of cardiovascular active...

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Abstract

The invention is suitable for the field of traditional Chinese medicine and provides a method for screening active ingredients of traditional Chinese medicine. The method comprises the following steps: preparing a chromatographic column; preparing Danhong sample liquid; and screening through the chromatographic column. The method successfully screens out the active ingredients for cardiovascular and cerebrovascular diseases in Danhong injection, the screening efficiency is improved, and meanwhile the safety of the Danhong injection is greatly improved.

Description

technical field [0001] The invention belongs to the field of new materials, and in particular relates to a method for screening active ingredients of traditional Chinese medicines. Background technique [0002] Traditional Chinese medicine injections are commonly used clinically for the treatment of cardiovascular diseases. Traditional Chinese medicine injection refers to under the guidance of traditional Chinese medicine theory, using advanced preparation technology, the single or compound prescription of traditional Chinese medicine or natural medicine is made into preparations that can be injected into the body, including muscle, acupuncture point, intradermal, subcutaneous, intravenous injection and other tissues and organs. Sterile preparations for injection and sterile powders or concentrates for preclinical preparation of solutions. Compared with traditional dosage forms, traditional Chinese medicine injections have the characteristics of rapid drug effect and no dig...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/89
Inventor 王雪艳郑晓晖裴渭静唐旭东
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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