Sugar alcohol phosphate thiazolidine-4-carboxy compound and application thereof

A technology of carboxylic acid compound and tetrahydrothiazole, which is applied in the field of phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compound, can solve the problems of affecting the body's motor function, low ATP content, body organ damage, etc., and achieve anti-inflammatory Effects of detoxification ability, increasing ATP level, and increasing concentration

Inactive Publication Date: 2014-09-24
魏景芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of ATP itself in the body is not high, especially in the state of hypoxia and ischemia, the body's ATP will drop sign

Method used

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  • Sugar alcohol phosphate thiazolidine-4-carboxy compound and application thereof
  • Sugar alcohol phosphate thiazolidine-4-carboxy compound and application thereof
  • Sugar alcohol phosphate thiazolidine-4-carboxy compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Weigh 27.4 kg of D-ribose-5-phosphate disodium salt, stir with 50 kg of deionized water until completely dissolved, add 12.2 kg of calcium chloride solid in 18 kg of water, and stir at room temperature for more than 12 hours. Add 150 kg of ethanol, stir for 2 hours, filter, collect the solid, wash with ethanol, and obtain 25.5 kg of white solid product as D-ribose-5-phosphate calcium salt. In a nitrogen-protected reaction vessel, weigh 25.5 kg of D-ribose-5-phosphate calcium salt, add 100 kg of deionized water and stir until completely dissolved, then add 15 kg of L-cysteine ​​hydrochloride, and stir until completely Dissolve, add 7.52 kg of pyridine, and stir at room temperature for more than 24 hours. Add 300 kg of ethanol, lower the temperature to less than 5 degrees Celsius, stir for 2 hours, filter and wash with cold ethanol to obtain 30.36 kg of white solid product. The yield was 86%, and the product was confirmed by NMR, IR and mass spectrometry.

Embodiment 2

[0059] Weigh 27.4 kg of D-ribose-5-phosphate disodium salt, stir with 50 kg of deionized water until completely dissolved, add 13.94 kg of ferrous chloride dissolved in 25 kg of water, and stir at room temperature for more than 12 hours. Add 150 kg of ethanol, stir for 2 hours, filter, collect the solid, wash with ethanol, and obtain 26.9 kg of white solid product which is ferrous D-ribose-5-phosphate. In a nitrogen-protected reaction vessel, weigh 26.9 kilograms of D-ribose-5-ferrous phosphate, add 100 kilograms of deionized water and stir until completely dissolved, then add 15 kilograms of D-cysteine ​​hydrochloride, and stir until After completely dissolving, 7.52 kg of pyridine was added and stirred at room temperature for more than 24 hours. Add 300 kg of ethanol, lower the temperature to less than 5 degrees Celsius, stir for 2 hours, filter and wash with cold ethanol to obtain 29.78 kg of white solid product. The yield was 81%, and the product was confirmed by NMR, IR ...

Embodiment 3

[0061]Weigh 27.4 kg of D-ribose-5-phosphate disodium salt, add 50 kg of deionized water and stir until completely dissolved, then add 16 liters of saturated calcium chloride solution, and stir at room temperature for more than 12 hours. Add 150 kg of ethanol, stir for 2 hours, filter, collect the solid, wash with ethanol, and obtain 25.5 kg of white solid product as D-ribose-5-phosphate calcium salt. In a nitrogen-protected reaction vessel, weigh 25.5 kg of D-ribose-5-phosphate calcium salt, add 100 kg of deionized water and stir until completely dissolved, then add 15 kg of L-cysteine ​​hydrochloride and D-cysteine Cystine hydrochloride is a 50:50 mixture by weight, stirred until completely dissolved, added 7.52 kg of pyridine, and stirred at room temperature for more than 24 hours. Add 300 kg of ethanol, lower the temperature to below 5°C, stir for 2 hours, filter and wash with cold ethanol to obtain 30 kg of white solid product. The yield was 85%, and the product was confi...

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Abstract

The invention relates to a sugar alcohol phosphate thiazolidine-4-carboxy compound with the structural formula as the specification. The compound is formed by integrating three groups and can release cysteine and ribose phosphate after being absorbed in vivo. Cysteine can be used for increasing the concentration of glutathione (GSH) in cells, improving the oxidation resistance of the cells and improving the inflammation diminishing and detoxifying capabilities of a human body from inside to outside. Ribose phosphate can be used for replenishing the energy loss caused by wounds or strenuous exercise while rapidly and effectively improving the ATP (Adenosine Triphosphate) level in tissues. Bodybuilding and brain-strengthening effects can be synchronously realized through the combination of carboxylate and phosphate groups and different trace elements.

Description

technical field [0001] The invention belongs to the field of phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compounds, and specifically refers to a phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compound and an application thereof. Background technique [0002] Glutathione (GSH) is present in nearly every cell of the body. It can help the body maintain normal immune system functions, and has antioxidant and integrated detoxification effects. The sulfhydryl group on cysteine ​​is its active group, which is easy to interact with certain drugs (such as paracetamol), toxins (such as free radicals) , iodoacetic acid, mustard gas, heavy metals such as lead, mercury, arsenic), etc., so that harmful poisons in the body are converted into harmless substances, excreted out of the body, and have a detoxification effect. Another main physiological role of glutathione is as an important antioxidant in the body. It can remove free radicals in the human body,...

Claims

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Application Information

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IPC IPC(8): C07F9/6539A61K31/675A61P39/02A61P39/06A61P29/00
Inventor 魏景芬魏景强苏伟平阚剑张星姜志良
Owner 魏景芬
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