Sugar alcohol phosphate thiazolidine-4-carboxy compound and application thereof
A technology of carboxylic acid compound and tetrahydrothiazole, which is applied in the field of phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compound, can solve the problems of affecting the body's motor function, low ATP content, body organ damage, etc., and achieve anti-inflammatory Effects of detoxification ability, increasing ATP level, and increasing concentration
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Embodiment 1
[0057] Weigh 27.4 kg of D-ribose-5-phosphate disodium salt, stir with 50 kg of deionized water until completely dissolved, add 12.2 kg of calcium chloride solid in 18 kg of water, and stir at room temperature for more than 12 hours. Add 150 kg of ethanol, stir for 2 hours, filter, collect the solid, wash with ethanol, and obtain 25.5 kg of white solid product as D-ribose-5-phosphate calcium salt. In a nitrogen-protected reaction vessel, weigh 25.5 kg of D-ribose-5-phosphate calcium salt, add 100 kg of deionized water and stir until completely dissolved, then add 15 kg of L-cysteine hydrochloride, and stir until completely Dissolve, add 7.52 kg of pyridine, and stir at room temperature for more than 24 hours. Add 300 kg of ethanol, lower the temperature to less than 5 degrees Celsius, stir for 2 hours, filter and wash with cold ethanol to obtain 30.36 kg of white solid product. The yield was 86%, and the product was confirmed by NMR, IR and mass spectrometry.
Embodiment 2
[0059] Weigh 27.4 kg of D-ribose-5-phosphate disodium salt, stir with 50 kg of deionized water until completely dissolved, add 13.94 kg of ferrous chloride dissolved in 25 kg of water, and stir at room temperature for more than 12 hours. Add 150 kg of ethanol, stir for 2 hours, filter, collect the solid, wash with ethanol, and obtain 26.9 kg of white solid product which is ferrous D-ribose-5-phosphate. In a nitrogen-protected reaction vessel, weigh 26.9 kilograms of D-ribose-5-ferrous phosphate, add 100 kilograms of deionized water and stir until completely dissolved, then add 15 kilograms of D-cysteine hydrochloride, and stir until After completely dissolving, 7.52 kg of pyridine was added and stirred at room temperature for more than 24 hours. Add 300 kg of ethanol, lower the temperature to less than 5 degrees Celsius, stir for 2 hours, filter and wash with cold ethanol to obtain 29.78 kg of white solid product. The yield was 81%, and the product was confirmed by NMR, IR ...
Embodiment 3
[0061]Weigh 27.4 kg of D-ribose-5-phosphate disodium salt, add 50 kg of deionized water and stir until completely dissolved, then add 16 liters of saturated calcium chloride solution, and stir at room temperature for more than 12 hours. Add 150 kg of ethanol, stir for 2 hours, filter, collect the solid, wash with ethanol, and obtain 25.5 kg of white solid product as D-ribose-5-phosphate calcium salt. In a nitrogen-protected reaction vessel, weigh 25.5 kg of D-ribose-5-phosphate calcium salt, add 100 kg of deionized water and stir until completely dissolved, then add 15 kg of L-cysteine hydrochloride and D-cysteine Cystine hydrochloride is a 50:50 mixture by weight, stirred until completely dissolved, added 7.52 kg of pyridine, and stirred at room temperature for more than 24 hours. Add 300 kg of ethanol, lower the temperature to below 5°C, stir for 2 hours, filter and wash with cold ethanol to obtain 30 kg of white solid product. The yield was 85%, and the product was confi...
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