Methylacrylic acid (MAA) contained medical polylactic acid (PLA) derivative material

Abstract

The invention discloses a methylacrylic acid (MAA) contained medical polylactic acid (PLA) derivative material which is prepared through the following steps: with L-lactide as a raw material, synthesizing three-arm or multi-arm star-shaped PLA by using a classical stannous octoate catalyzed ring-opening method, and due to the existence of hydroxyl at the terminal of a polymer, enabling three-arm or multi-arm star-shaped PLA to react with bromoisobutyryl bromide in ice bath to obtain a star-shaped macroinitiator SPLA-Br of a bromo-terminal functional group; carrying out ATRP (Atom Transfer Radical Polymerization) on the macroinitiator and MAA according to a certain ratio to obtain a star-shaped PMAA block polymer with PLA as a core, then, adding N-isopropylacrylamide, and carrying out ATRP again to obtain a triblock copolymer; adding PMAA with low-molecular weight, and dissolving PMAA with water by means of the amphipathicity of the block copolymer to form a nanoporous material. The block copolymer is of a hexagonal prism shaped structure, contains PLA as a continuous phase and is provided with nano-grade micropores. The material has the following advantages that the material is provided with the nano-grade micropores; the defect of poor processability of the traditional linear PLA material is overcome; no toxic or side effect is generated; the material can be used as a drug carrier material, a medical implant material and an in-vivo continuous dosing device part material.

Description

Technical field [0001] The invention relates to a degradable polylactic acid material, in particular to a preparation method of a block polymer material with nanoscale micropores. The invention belongs to the field of polymer chemistry and polymer technology. Background technique [0002] Polylactic acid (PLA) is a new generation of fully degradable polymer materials developed rapidly in the 1990s. It has excellent biocompatibility and is approved by the US Food and Drug Administration (FDA). A class of biomedical materials and environmental protection materials. Since the 1960s, scientists began to pay attention to the degradation performance of polylactic acid materials, and for the first time used polylactic acid materials as degradable surgical suture materials. In 1966, Kulkarni et al. (Kricheldorf H. R. Chemosphere 2001, 43, 49-54. It was first proposed that low molecular weight PLA can be degraded in vivo, and the final metabolite is CO 2 and H 2 O, harmless to ...

AI Technical Summary

Problems solved by technology

Through our review of literature, there is no polylactic acid material that has the characteristics of high processing performance, hydrophilicity, excellent biodegradability, nanoscale micropores, and high drug loading capacity.

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