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Novel application of oxiracetam or levo-oxiracetam in field of pharmaceuticals

A technology of medicine and pharmacy, which is applied to the new application field of oxiracetam or levoxiracetam in the pharmaceutical field, and can solve the problems of hallucinations and confusion of consciousness.

Active Publication Date: 2014-10-08
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these clinically used drugs have adverse effects, such as donepezil can cause side effects such as diarrhea, muscle cramps, fatigue, nausea, vomiting and insomnia; memantine can cause side effects such as hallucinations, confusion, dizziness, headache and fatigue, so There is a need to develop new drugs for the treatment of cognitive impairment

Method used

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  • Novel application of oxiracetam or levo-oxiracetam in field of pharmaceuticals
  • Novel application of oxiracetam or levo-oxiracetam in field of pharmaceuticals
  • Novel application of oxiracetam or levo-oxiracetam in field of pharmaceuticals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0155] Raw material composition:

[0156] (a) Levoxiracetam (99.5% pure) 200mg / capsule

[0157](b) Lactose 80mg / capsule

[0158] (c) Microcrystalline cellulose 70mg / capsule

[0159] Taking the preparation of 1000 levoxiracetam capsules as an example, the specific preparation method is: first pass the raw and auxiliary materials through an 80-mesh sieve, weigh the prescribed amount of levoxiracetam, lactose, and microcrystalline cellulose and mix evenly, directly Fill the capsule.

Embodiment 2

[0161] Raw material composition:

[0162]

[0163]

[0164] Take making 1000 levoxiracetam tablets as an example, the specific preparation method is: first pass the raw and auxiliary materials through an 80-mesh sieve, weigh the prescribed amount of levoxiracetam, starch, and microcrystalline cellulose and mix evenly, add 2% HPMC aqueous solution is used to prepare soft materials, granulate, dry, and granulate, add prescription amount of talcum powder to the granules, mix evenly, and compress into tablets.

Embodiment 3

[0166] Raw material composition:

[0167]

[0168] Taking the preparation of 1000 levoxiracetam capsules as an example, the specific preparation method is as follows: the raw and auxiliary materials are first passed through an 80 mesh sieve, and the prescribed amount of levoxiracetam, lactose, and sodium starch glycolate are mixed evenly. Add 10% PVP ethanol solution to make soft material, granulate, dry, granulate, add prescription amount of talcum powder to the granules, mix evenly, and fill the capsules.

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Abstract

The invention provides application of oxiracetam or levo-oxiracetam in preparation of medicines for preventing or treating neurofunction deficit. The experimental result proves that oxiracetam is obvious in effect of treating ischemic neurofunction deficit caused by cerebral infarction; and the levo-oxiracetam is obvious in effects of treating ischemic neurofunction deficit caused by cerebral infarction and treating neurofunction deficit caused by trauma.

Description

technical field [0001] The present invention relates to the medical use of oxiracetam, in particular to the application of oxiracetam or levo-oxiracetam in the preparation of drugs for preventing or treating neurological deficits. Background technique [0002] Levo-oxiracetam ((S)-4-hydroxy-2-oxo-1-pyrrolidineacetamide) is the levorotatory form of oxiracetam (Oxiracetam CAS62613-82-5), a white microcrystalline powder, The melting point is 135-136°C, and the optical rotation is -36.0° (C=1.00in water). The solubility of levoxiracetam is obviously better than that of the mixed form. Oxiracetam is a synthetic cyclic derivative of hydroxyaminobutyric acid (GABOB), which can promote ATP in the brain, promote the synthesis of acetylcholine and enhance the conduction of nerve excitation, and can improve the retrograde amnesia caused by hypoxia. It can enhance memory and improve learning ability. Since the clinical effect of oxiracetam for the treatment of mental retardation has n...

Claims

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Application Information

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IPC IPC(8): A61K31/4015A61P25/28A61P25/00A61P9/10
CPCA61K31/4015
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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