Application of domperidone in preparation of therapeutics for cerebral ischemia-reperfusion injury
A technology of cerebral ischemia-reperfusion and domperidone, which is applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of undiscovered domperidone, etc.
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[0023] 1 Experimental method
[0024] 1.1 Establishment of MCAO mouse model
[0025] (1) Experimental animals and sources
[0026] 72 male wild-type C57 / BL6 pathogen-free (SPF grade) mice, aged 6-8 weeks, weighing 25-30 g, were kept in a room temperature of 20-25°C and a relative humidity of 40%-60%.
[0027] (2) Experimental grouping
[0028] For studying the drug action of domperidone in mouse MCAO animal model, mice are divided into three groups at random, 24 in every group, are respectively sham operation group; Ischemia-reperfusion model group (model group); Domperidone treatment group (treatment group). ). Domperidone 50 mg / Kg / day was given by intragastric administration to the treatment group and 7 days before the preparation of the MCAO model. The sham operation group and the model group were given intragastric administration of the same volume of normal saline as the treatment group 7 days before the MCAO model preparation. The mice in model group and treatment g...
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