Novel application of oxiracetam or levo-oxiracetam in pharmaceutical field

A technology of drugs and compounds, applied in the new application field of oxiracetam or levoxiracetam in the pharmaceutical field, can solve problems such as hallucinations and confusion of consciousness

Active Publication Date: 2016-03-16
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these clinically used drugs have adverse effects, such as donepezil can cause side effects such as diarrhea, muscle cramps, fatigue, nausea, vomiting and insomnia; memantine can cause side effects such as hallucinations, confusion, dizziness, headache and fatigue, so There is a need to develop new drugs for the treatment of cognitive impairment

Method used

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  • Novel application of oxiracetam or levo-oxiracetam in pharmaceutical field
  • Novel application of oxiracetam or levo-oxiracetam in pharmaceutical field
  • Novel application of oxiracetam or levo-oxiracetam in pharmaceutical field

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0155] Raw material composition:

[0156] (a) Levoxiracetam (99.5% pure) 200mg / capsule

[0157] (b) Lactose 80mg / grain

[0158] (c) Microcrystalline cellulose 70mg / capsule

[0159]Taking the preparation of 1000 levoxiracetam capsules as an example, the specific preparation method is: first pass the raw and auxiliary materials through an 80-mesh sieve, weigh the prescribed amount of levoxiracetam, lactose, and microcrystalline cellulose and mix evenly, directly Fill the capsule.

Embodiment 2

[0161] Raw material composition:

[0162]

[0163]

[0164] Take making 1000 levoxiracetam tablets as an example, the specific preparation method is: first pass the raw and auxiliary materials through an 80-mesh sieve, weigh the prescribed amount of levoxiracetam, starch, and microcrystalline cellulose and mix evenly, add 2% HPMC aqueous solution is used to prepare soft materials, granulate, dry, and granulate, add prescription amount of talcum powder to the granules, mix evenly, and compress into tablets.

Embodiment 3

[0166] Raw material composition:

[0167]

[0168] Taking the preparation of 1000 levoxiracetam capsules as an example, the specific preparation method is as follows: the raw and auxiliary materials are first passed through an 80 mesh sieve, and the prescribed amount of levoxiracetam, lactose, and sodium starch glycolate are mixed evenly. Add 10% PVP ethanol solution to make soft material, granulate, dry, granulate, add prescription amount of talcum powder to the granules, mix evenly, and fill the capsules.

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Abstract

Provided is an application of oxiracetam or levo oxiracetam for preparing a drug preventing or treating neurofunction deficit. Experimental results show that oxiracetam has a noticeable effect as a treatment for ischemic neurofunction deficit resulting from a cerebral infarction, and levo oxiracetam has a noticeable effect as a treatment for ischemic neurofunction deficit resulting from a cerebral infarction or trauma.

Description

technical field [0001] The present invention relates to the medical use of oxiracetam, in particular to the application of oxiracetam or levo-oxiracetam in the preparation of drugs for preventing or treating neurological deficits. Background technique [0002] Levo-oxiracetam ((S)-4-hydroxy-2-oxo-1-pyrrolidineacetamide) is the levorotatory form of oxiracetam (OxiracetamCAS62613-82-5), a white microcrystalline powder, melting point 135~136°C, the optical rotation is -36.0°(C=1.00inwater), the solubility of levo-oxiracetam is obviously better than that of the mixed body. Oxiracetam is a synthetic cyclic derivative of hydroxyaminobutyric acid (GABOB), which can promote ATP in the brain, promote the synthesis of acetylcholine and enhance the conduction of nerve excitation, and can improve the retrograde amnesia caused by hypoxia. Can enhance memory and improve learning ability. Since the clinical effect of oxiracetam for the treatment of mental retardation has not yet reached ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4015A61P25/28A61P25/00A61P9/10
CPCA61K31/4015
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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