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A kind of bone repair material and preparation method thereof

A technology of bone repair and aqueous solution, applied in the field of medical materials, can solve the problems of increased probability of secondary infection of germs, poor surgical results, joint dysfunction, etc., achieve low price, broad market application prospects, and reduce infection complications Effect

Inactive Publication Date: 2016-03-16
福州市第二医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, debridement, perfusion, and other methods are mostly used for related surgical treatment. The treatment cycle is long, the number of operations is high, and the probability of secondary infection of the wound site increases, resulting in poor surgical results. Deformity, joint dysfunction and other disabilities

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] Further, in the preparation method of the bone repair material, in step S5, pouring the mixture obtained in step S4 into a mold for solidification and molding further includes a step of removing air bubbles.

[0029] Further, in the preparation method of the bone repair material, the reaction temperature in step S1 is 25-37 degrees Celsius, and the reaction is carried out in an inert gas atmosphere.

[0030] Further, in the preparation method of the bone repair material, the reducing agent includes freshly prepared ascorbic acid or sodium borohydride.

[0031] Further, in the preparation method of the bone repair material, the stirring speed in step S1 is 60-200 rpm.

[0032] Further, in the preparation method of the bone repair material, the calcium sulfate powder in step S4 includes calcium sulfate dihydrate or α-type calcium sulfate hemihydrate.

[0033] Further, in the preparation method of the bone repair material, the calcium sulfate dihydrate is a powder with a ...

no. 1 example

[0037] Mix 5 milliliters of 10 mmol / liter silver nitrate aqueous solution and 5 milliliters of 10 mg / ml collagen solution, and stir for 15 minutes at a speed of 100 revolutions / minute at 25 degrees Celsius under the protection of a nitrogen atmosphere, so that the free Ag in the system The ions are combined with the amino acid residues of collagen, then the pH value is adjusted to 12 with sodium hydroxide solution, 100 microliters of 10 mmol / liter freshly prepared ascorbic acid solution is added, and the reaction is stirred at 25 degrees Celsius for 15 minutes to obtain collagen-coated nanoparticles. In the silver composite, the size of the nano-silver particles is between 10 nanometers and 200 nanometers. Then add 25 mg of calcium sulfate dihydrate with 100-500 mesh sieve and 100 mg of α-type calcium sulfate hemihydrate powder with 100-500 mesh sieve and stir for 5 minutes, pour the resulting slurry into the mold, remove air bubbles, and remove the mold after curing The bone ...

no. 2 example

[0039] Mix 5 milliliters of 50 mmol / liter silver nitrate aqueous solution and 5 milliliters of 10 mg / ml collagen solution, and stir for 15 minutes at a speed of 100 revolutions / minute at 25 degrees Celsius under the protection of a nitrogen atmosphere, so that the free Ag in the system The ions are combined with the amino acid residues of collagen, then the pH value is adjusted to 12 with sodium hydroxide solution, 100 microliters of 10 mmol / L freshly prepared ascorbic acid solution is added, and the reaction is stirred at 25 degrees Celsius for 15 minutes to obtain collagen-coated Nano-silver composite, the size of nano-silver particles is between 10 nanometers and 200 nanometers. Then add 25 mg of calcium sulfate dihydrate with 100-500 mesh sieve and 100 mg of α-type calcium sulfate hemihydrate powder with 100-500 mesh sieve and stir for 5 minutes, pour the resulting slurry into the mold, remove air bubbles, and remove the mold after curing The bone repairing material with a...

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Abstract

The invention discloses a bone repair material and a preparation method thereof. The preparation method comprises the steps of adding 10-50 mg / ml collagen aqueous solution into 10-50 mmol / L silver nitrate aqueous solution under stirring; reacting for 15-120 minutes, a volume of the silver nitrate aqueous solution being identical to that of the collagen aqueous solution; adjusting a pH of the obtained mixture to 12-14; adding a reducing agent into the obtained mixture; reacting for 15-30 minutes; adding calcium sulfate powder in the obtained mixture under stirring, calcium sulfate accounting for 20-30% by mass of a total reaction system; and pouring the obtained mixture into a mold for curing. The bone repair material can effectively reduce infection complication caused by bone implant materials, increases a curative effect of the bone implant materials, is very suitable for clinical treatment of large-area bone trauma, and has wide market application prospects.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a bone repair material and a preparation method thereof. Background technique [0002] With the continuous development of urban development and highway mileage, the trauma (especially bone injury) caused by traffic accidents is increasing. Clinically, bone injuries caused by such trauma are often accompanied by fractures, bone exposure, bone defects, etc., and the condition is complicated and difficult to treat. Among them, open wounds are wounds with a high infection rate. It has the characteristics of serious wound pollution and multiple complex injuries. Improper wound treatment will greatly increase the wound infection rate and directly endanger the prognosis of the wounded. At present, debridement, perfusion, and other methods are often used for related surgical treatment. The treatment cycle is long, the number of operations is high, and the probability of secondary infec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/54A61L27/58
Inventor 林焱斌张韬李仁斌庄研熊国胜熊圣仁张怡元
Owner 福州市第二医院
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