Device for diagnosing advanced liver fibrosis

A technique for liver fibrosis, logistic function, applied in the field of improving diagnostic tests, which can solve problems such as lack of reliability of liver biopsy

Inactive Publication Date: 2018-04-10
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] However, as noted above, since liver biopsy cannot be considered an absolute criterion for liver fibrosis, it is impossible for non-invasive diagnostic methods to achieve values ​​above 0.9 for this disease
[0013] Therefore, continuous improvement of non-invasive diagnostic methods is warranted, given the lack of reliability of liver biopsy in some cases

Method used

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  • Device for diagnosing advanced liver fibrosis
  • Device for diagnosing advanced liver fibrosis
  • Device for diagnosing advanced liver fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0121] Materials and methods

[0122] method

[0123] patient

[0124] A previously described integrated database [13] comprising 1893 subjects was used: three cohorts of patients with CHC (n=1289), and one cohort of apparently healthy volunteers (healthy cohort, n=604).

[0125] Patients to be enrolled must have chronic hepatitis C, be PCR positive, and have results of liver biopsy, fibrosis test (FibroTest), LSM interpretable according to commonly used recommendations and precautions. In all these groups, each test was performed without knowledge of the other three.

[0126] To clarify the specificity of each test, a group of 604 healthy volunteers without any risk of liver disease was analyzed, since the probability of true advanced liver fibrosis is very low.

[0127] Inclusion criteria were: no history of liver disease, no or low alcohol consumption (≤10g / day for women, ≤20g / day for men), negative for HBsAg, negative for HCV antibodies, and and LSM results are interp...

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Abstract

The present invention relates to a device for diagnosing advanced liver fibrosis. Specifically, the device for diagnosing advanced liver fibrosis comprises a first device and a second device, wherein the first device combines the α2-macroglobulin measured in the patient's serum or plasma by a first logistic function , haptoglobin, apolipoprotein A1, total bilirubin, γ-glutamine-transpeptidase (GGT) values ​​provide a first index, the second device combines the first index and the second by a second logistic function Index provides the final index. The present invention relates to a new diagnostic method in the field of hepatology combining serum markers and measurements of liver elasticity.

Description

technical field [0001] The present invention relates to new diagnostic methods in the field of hepatology and general methods for improving diagnostic tests in the absence of absolute standards. Background technique [0002] Over the past few years, different diagnostic methods have been developed that allow the detection of liver diseases by measuring serum markers, which replace liver biopsies. In particular, one can cite WO 2002 / 016949 describing (FT) (sold by Biopredictive (Paris, France)), and use (sold by Echosens, Paris, France) to measure liver stiffness (LSM). [0003] Use of these methods can reduce the number of biopsies previously considered necessary for the management of patients with liver disease, (particularly those infected with hepatitis C virus (HCV)), especially for fibrosis in installments. Liver biopsy is indeed an invasive step. [0004] (FT), and using Liver stiffness measurement (LSM) is now the most effective technique for non-invasive a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/20G16B20/00
CPCG16H50/20G16Z99/00G16B20/00G16B25/10C12Q1/48G01N33/5091
Inventor T·普纳德
Owner ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
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