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Detection device of immune multiple-reaction mass spectrum

A detection device and mass spectrometry detection technology, applied in the field of biomedical analysis, can solve problems such as the lack of protein quantification technology and the stoppage of biomarker research

Inactive Publication Date: 2014-10-15
江苏金太生命科技有限公司
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AI Technical Summary

Problems solved by technology

However, the lack of protein quantification techniques available for medical testing has halted extensive biomarker research

Method used

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Embodiment Construction

[0005] The core technology includes two parts: multi-reaction mass spectrometry detection and immunoenrichment of protein biomarkers. Multi-reaction mass spectrometry is an instrument that uses triple quadrupoles in mass spectrometry, and its operating mode is called multiple reaction monitoring (MRM). Combined with isotope-labeled peptide standards and specific ion transitions, multi-reaction mass spectrometry detection has the characteristics of high sensitivity detection. Combined with antibody immuno-enrichment technology, low-concentration biomarkers in biological fluids (such as blood, saliva, etc.) can be standardized and quantified, thereby providing a practical basis for early diagnosis of diseases.

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Abstract

The invention discloses a detection device of immune multiple-reaction mass spectrum. The device comprises a multiple-reaction mass spectrum detection part and a protein biomarker immunization enrichment part. Multiple-reaction mass-spectrometric technique is to use triple quadrupole instrument, and an operation mode of is called multiple-reaction monitoring (MRM). Combined with isotope labeled polypeptide reference substance and specific ion transition, the multiple-reaction mass detection has the characteristic of high sensitivity detection. Combined with antibody immunization enrichment technology, low concentration biomarkers in biological fluids (such as blood and saliva) can be quantified according to the standard, so as to provide practical basis for early diagnosis of disease.

Description

Technical field [0001] The invention relates to a detection device, in particular to a detection device of immune multi-reaction mass spectrometry, and belongs to the technical field of biomedical analysis. Background technique [0002] Our human protein quantitative detection technology is different from other protein quantitative technologies. Our technology aims to directly transform the research results of disease biomarkers into clinical benefits. The difference from other projects is that we will develop very specific quantitative detection of candidate biomarkers by immunological multi-reaction mass spectrometry, so as to transform these candidate biomarkers into clinical use. Existing biomarker research is developing rapidly, and candidate biomarkers for various diseases appear in large numbers. However, the lack of protein quantification technology that can be used for medical testing has stopped a large number of biomarker research. The immunological multi-reaction ma...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N1/40
Inventor 张震海
Owner 江苏金太生命科技有限公司
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