Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ophthalmic and otorhinolaryngological device materials containing a multi-arm peg macromer

A technology of ENT and ophthalmology, applied in the field of ophthalmology and ENT device materials containing multi-arm PEG macromers

Inactive Publication Date: 2014-11-05
NOVARTIS AG
View PDF11 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Likewise, higher molecular weight PEG dimethacrylates cannot be mixed with hydrophobic acrylic monomers

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ophthalmic and otorhinolaryngological device materials containing a multi-arm peg macromer
  • Ophthalmic and otorhinolaryngological device materials containing a multi-arm peg macromer
  • Ophthalmic and otorhinolaryngological device materials containing a multi-arm peg macromer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Partially Methacrylated 2000M n Synthesis of 4-arm PEG, Batch #1

[0090] Commercially available 4-arm polyethylene glycol was degassed at 70°C for 4 days and then dissolved in about 100 ml THF. Triethylamine and p-methoxyphenol (ca. 50 mg) were added and the mixture was cooled to 0°C. Add methacryloyl chloride dropwise. Formation of triethylamine-HCl salt started immediately. The mixture was stirred at ambient temperature for 72 hours, then filtered through a plug of silica using a medium porosity sintered glass funnel. The silica was rinsed with dichloromethane so the total volume of the filtrate was about 500-700ml. The solvent was removed by rotary evaporation and the product was dried under vacuum for 3-4 days to give a light yellow liquid (yield 60%).

[0091] Reaction table showing the synthesis of 4-arm PEG using 1.5 equivalents of methacryloyl chloride

[0092]

Embodiment 2

[0094] Partially Methacrylated 2000M n Synthesis of 4-arm PEG, Batch #2

[0095] Procedure: same as Example 1. Pale yellow liquid (yield about 60%).

[0096] Reaction table showing the synthesis of 4-arm PEG using 3.5 equivalents of methacryloyl chloride

[0097]

Embodiment 3

[0099] IOL preparation

[0100] The multi-armed PEG derivatives from Examples 1 and 2 were formulated as shown in Tables 1 and 2. Specimens measuring a thickness of 0.9 mm were cured thermally at 70°C for 1 hour and at 110°C for 2 hours. Samples were extracted in acetone for 20 hours at 55°C, then slowly dried at ambient temperature for 20 hours, followed by vacuum (0.1 mm Hg) at 70°C for a minimum of 20 hours. The extractable weight percent, equilibrium water content (EWC), refractive index (R.I.) and plate appearance of the hydrated samples subjected to the 45-22°C ΔT test are shown in Table 3. The mechanical and thermal properties of selected compositions are shown in Table 4.

[0101] Table 1

[0102]

[0103] Table 2

[0104]

[0105]

[0106] table 3

[0107]

[0108] 1 Samples were equilibrated in deionized water for 9 days at 45°C, then cooled to ambient temperature and later examined by light microscopy using a 10X objective for 1-2 hours.

[0109] ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Disclosed are soft, high refractive index, acrylic device materials. The materials contain a multi-arm PEG macromer.

Description

technical field [0001] The present invention relates to improved materials for ophthalmic and ENT devices. In particular, the present invention relates to soft, high refractive index, acrylic device materials comprising multi-armed polyethylene glycol macromers. Background of the invention [0002] With recent advances in small-incision cataract surgery, there has been increased emphasis on developing soft, foldable materials suitable for intraocular lenses. In general, these materials fall into one of three categories: hydrogels, silicon, and acrylic. [0003] In general, the relatively low refractive index of hydrogel materials makes them less desirable than other materials due to the thicker lens optics necessary to achieve a given refractive power. Traditional silicon materials typically have a higher refractive index than hydrogels, but tend to unfold explosively after being placed in the eye in a folded position. Explosive deployment may damage the corneal endotheli...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/16A61L27/50
CPCA61L27/50A61L2430/16A61L27/16C08L33/08
Inventor W·R·拉雷多
Owner NOVARTIS AG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com