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Use of benzopyridine derivative in preparation of anti-HIV (human immunodeficiency virus) drugs

A use, pharmaceutical technology, applied in the direction of antiviral agents, active ingredients of heterocyclic compounds, etc.

Inactive Publication Date: 2014-11-12
NANKAI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, inhibiting the activity of ZAP will cause a large amount of early viral proteins Tat and Nef to be produced, and the latently infected HIV virus will initiate replication.

Method used

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  • Use of benzopyridine derivative in preparation of anti-HIV (human immunodeficiency virus) drugs
  • Use of benzopyridine derivative in preparation of anti-HIV (human immunodeficiency virus) drugs
  • Use of benzopyridine derivative in preparation of anti-HIV (human immunodeficiency virus) drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Inhibitory activity of compounds against ZAP

[0039] In this embodiment test the compound represented by the following structure (i.e. R 1 and R 2 is the ZAP inhibitory activity of H). The compound number is HZC-010, obtained from Beijing Bailingwei Technology Co., Ltd.

[0040]

[0041] I. Materials and methods

[0042] 1. Test compound preparation:

[0043] Compound HZC-010 was dissolved in dimethyl sulfoxide (DMSO) at a concentration of 1 mol / L.

[0044] 2. Cell lines:

[0045] 293T cells (from ATCC: CRL-11268 TM )

[0046] Jurkat cell line (from ATCC: ATCC TIB-152 TM )

[0047] 3. Cell culture medium:

[0048] 1640 cell culture medium (90% RPMI Medium1640, Gibico)

[0049] 10% fetal bovine serum (FBS, Gibico)

[0050] 4. Other materials:

[0051] Luciferase activity assay system: Assay System (Cat. # 1500, Promega)

[0052] Transfection reagent: Lipofectamine TM 2000 (Invitrogen)

[0053] 5. Experimental method:

[0054] Two ps...

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Abstract

The present invention relates to new use of benzopyridine in preparation of drugs for preventing and / or treatment of acquired immunodeficiency syndrome (AIDS), and particularly relates to use of a compound shown as formula I or pharmaceutically acceptable salts thereof in the preparation of the drugs for preventing and / or treatment of acquired immunodeficiency syndrome (AIDS) and ZAP (zinc finger antiviral protein) inhibitors.

Description

technical field [0001] The present invention relates to a new application of benzopyridine derivatives in the preparation of medicines for preventing and / or treating acquired immunodeficiency syndrome. The present invention further relates to the new application of benzopyridine derivatives in the preparation of ZAP inhibitors. Background technique [0002] Acquired immunodeficiency syndrome (Acquired immunodeficiency syndrome, AIDS), also known as AIDS, is a clinical syndrome that is prone to opportunistic infections and tumors caused by human immunodeficiency virus (HIV) infection. syndrome. HIV attacks the most important T4 lymphocytes in the body's immune system, thereby destroying the body's immune system and eventually causing it to collapse. When the immune function of the infected person is severely damaged by the virus and cannot maintain the lowest resistance, the patient develops into AIDS. So far, more than 60 million people in the world have been infected wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61P31/18
Inventor 徐峰高光侠刘迎芳刘侃侃徐义辉
Owner NANKAI UNIV
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