Pharmaceutical composition for relieving pain and application thereof

A composition and drug technology, applied in the direction of drug combination, antipyretics, pharmaceutical formulas, etc., can solve serious problems, gastrointestinal reactions, addiction, etc., to reduce dosage, reduce side effects, and good therapeutic effect Effect

Active Publication Date: 2014-11-19
DALIAN UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, long-term use of NSAIDs and opioids can ca

Method used

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  • Pharmaceutical composition for relieving pain and application thereof
  • Pharmaceutical composition for relieving pain and application thereof
  • Pharmaceutical composition for relieving pain and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 实施例1 药物组合物对醋酸引起的小鼠扭体次数的影响

[0022] 雄性ICR小鼠(20±2)g,按体重随机分组,每组10只,各组分别通过灌胃给予治疗药物。 模型组灌胃给予等体积生理盐水。 小鼠腹腔注射醋酸,引起腹腔深部大面积而较持久的疼痛刺激,致使小鼠产生扭体反应。 各剂量组给药1h后,腹腔注射0.7%醋酸生理盐水溶液0.1ml / 10g,记录自注射醋酸致痛后每只小鼠在20min内出现的扭体反应次数,计算各给药组的扭体 Inhibition rate.

[0023] 扭体抑制率=[(对照组扭体次数-药物组扭体次数) / 对照组扭体次数]×100%

[0024] 给药组中单体药物之间重量比参见下表:

[0025]

Rosmarinic Acid

Tetrahydropalmatine

Mangiferin

Diclofenac Sodium

Dosing group 1

3

6

5

3

Dosing group 2

4

7

4

2

Dosing group 3

1

5

10

10

[0026] test results

[0027] 药物组合物对醋酸引起的小鼠扭体次数的影响

[0028] group

Embodiment 2

[0029] 实施例2 药物组合物对小鼠热板致痛反应的影响

[0030] 将雌性ICR小鼠(20±2)g,置55±0.5℃的智能热板仪上,记录小鼠足底接触热板至出现舔后足反应的潜伏期(s)为痛阈指标,剔除反应潜伏期30s或跳跃的小鼠。选取140只反应潜伏期在10~30s内的合格小鼠,根据药前痛阈和体重随机分组,灌胃给药;

[0031] 模型组:等体积的生理盐水,

[0032] 组合物组:50mg / kg,ig

[0033] 连续灌胃给药5天,于末次给药后30、60、90、120min时分别测定各给药组小鼠的痛阈1次,痛阈值超过60s者以60s计算。

[0034] 数据以 表示,采用SPSS15.0软件进行方差分析。

[0035] The specific results are as follows:

[0036] 药物组合物对小鼠热板致痛反应的影响

[0037]

[0038]

Embodiment 3

[0039] 实施例3 药物组合物对癌症疼痛的临床治疗效果

[0040] 一般资料:选择癌症疼痛患者200例,年龄32~65岁,体重45~75kg,平均年龄为43.5岁,平均体重为64.3kg。经辅助检查明确诊断,就诊前未进行镇痛治疗,无并发症。200例患者随机分为2组,每组100例。

[0041] 各组分别按下述方式服药:

[0042] 本发明药物组合物组:每次口服使用实施例1中的给药组2(60mg / 次),每日三次;

[0043] 双氯芬酸钠组:口服双氯芬酸钠60mg,每日三次;

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Abstract

The invention relates to the field of medicines, and particularly relates to a pharmaceutical composition for relieving pain. The pharmaceutical composition is prepared from the following components: rosmarinic acid, tetrahydropalmatine, mangiferin and diclofenac sodium in a weight ratio of (1-10):(1-10):(1-10):(1-10), preferably (2-4):(5-8):(3-6):(2-4), more preferably 3:6:5:3, or 4:7:4:2.

Description

technical field [0001] 本发明涉及药物领域,具体涉及一种用于镇痛的药物组合物及其制剂。 Background technique [0002] 疼痛是机体受到伤害性刺激后产生的一种保护性反应,经常伴有恐惧、紧张不安等情绪活动。疼痛除了反应在感觉上的痛苦与情绪上的不安外,还可导致生理功能的紊乱,引起失眠,甚至能诱发休克而危及生命。疼痛是癌症患者最常见的症状,约30-50%的癌症患者会有中到重度疼痛,尤其是晚期癌症的患者,约75-95%会发生难以控制的慢性疼痛,其中45%的癌症患者的疼痛剧烈无法缓解,而骨癌痛是其中最常见的难治类型,严重影响患者的生活质量。尽管WHO已经把癌痛治疗作为重要的社会问题,但目前仍缺乏有效的治疗手段。 [0003] 临床上常用的镇痛药一般分为两大类,作用于中枢神经系统的麻醉性镇痛药和作用于外周系统的非甾体消炎镇痛药(NSAID),中枢性镇痛药有很强的镇痛作用,但因其副作用大,尤其是易成瘾性而限制了其应用。非甾体消炎镇痛药是一类具有解热、镇痛和抗炎作用的药物,是治疗疼痛的基本药物,镇痛作用弱于前者,但副作用相对小,在治疗轻度及中等程度疼痛中被认为是一线首选药物。但是非甾体抗炎类药物与阿片类药物长期使用可引起严重的胃肠道反应和有成瘾性。 Contents of the invention [0004] 本发明的一个目的在于提供一种用于镇痛具有协同作用的药物组合物,该药物组合物由迷迭香酸、延胡索乙素、芒果苷和双氯芬酸钠组成。 [0005] 在本发明的一个实施方案中,所述迷迭香酸、延胡索乙素、芒果苷和双氯芬酸钠的重量比为1~10:1~10:1~10:1~10; [0006] 所述重量比进一步优选为2~4:5~8:3~6:2~4,更优选为3:6:5:3,也可以为4:7:4:2。 [0007] 本发明还提供上述药物组合物的用途,即该药物组合物在制备治疗疼痛药物中的应用。 [0008] 所述疼痛优选为癌症或妇女痛经导致的疼痛。 [0009] 上述所述的医药用途中,根据动物病情以及用药部位可以将上述药物组合物制备成合适的药物制剂以方便用药,对于本发明镇痛的药物组合物的给药时间和给药次数需要根据病情的具体诊断结果而定,这在本领域技术人员掌握的技术范围之内。例如,对于本领域技...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P25/04A61P29/00A61K31/196A61K31/216A61K31/352
Inventor 唐玲王姣
Owner DALIAN UNIV
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