Device and method for simulating oral dissolution of buccal no-smoke tobacco product

Abstract

The invention discloses a device and a method for simulating the oral dissolution of a buccal no-smoke tobacco product. The device is characterized by comprising a thermostable waterbath box, a double-channel peristaltic pump, a collecting bottle, and an artificial saliva container and an artificial oral cavity device which are both arranged in the thermostable waterbath box, wherein a dissolution vessel which is used for putting the buccal no-smoke tobacco product and can hold liquid is arranged in the artificial oral cavity device; a first pipeline and a second pipeline are respectively arranged on the double-channel peristaltic pump, an inlet of the first pipeline is positioned in the artificial saliva container, and an outlet of the first pipeline is positioned in the artificial oral cavity device and above the dissolution vessel. The dissolution device is simple in structure and low in cost, can ensure that both the upper surface and the lower surface of the buccal no-smoke tobacco product can be in contact with artificial saliva when the inhaling of the buccal no-smoke tobacco product is simulated, and can also ensure that the simulating inhaling temperature environment of the buccal no-smoke tobacco product is the constant-temperature environment of the oral cavity of the human body. The device is suitable for popularization and use.

Description

technical field [0001] The invention relates to a device for simulating dissolution in the oral cavity, in particular to a device for simulating the dissolution in the mouth of smokeless tobacco products in the mouth and a simulation method thereof. Background technique [0002] In recent years, as people continue to pay attention to the hazards of passive smoking, smokeless tobacco products are increasingly favored by consumers. However, some scholars have reported that the use of smokeless tobacco products may increase the risk of oral cancer and tongue cancer. Therefore, adequate toxicological evaluation of smokeless tobacco products in simulated human oral environment is an important manifestation of the supremacy of consumer interests. [0003] At present, the method of directly soaking or soaking after grinding is mainly used in the preparation of extractable samples of buccal-type smokeless tobacco products. The difference is far, which will affect the results of su...

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the purpose of the present invention is to provide a device for simulating the dissolution of oral smokeless tobacco products in the mouth, in order to solve the problem that the existing device ignores the constant temperature environment of the oral cavity at about 37°C and ignores the The upper and lower surfaces of the mouth-type smokeless tobacco products need to be in contact with saliva and many other deficiencies

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