Preparation method of silicon dioxide/octacalcium phosphate particles capable of releasing methylthionine chloride monomers

Abstract

The invention provides a preparation method of silicon dioxide / octacalcium phosphate particles capable of releasing methylthionine chloride monomers. The preparation method of silicon dioxide / octacalcium phosphate particles capable of releasing the methylthionine chloride monomers comprises the following steps: sequentially adding ammonium hydroxide, methylthionine chloride, tetraethoxysilane and a silane coupling agent into a solution containing water and ethyl alcohol, then stirring for 4 hours, centrifuging and washing the solution, then preparing the solution into a silicon dioxide colloidal solution containing methylthionine chloride by ethyl alcohol; then adding citric acid, calcium nitrate and diammonium hydrogen phosphate into the solution containing water and ethyl alcohol, adjusting pH value of the solution to 9 by ammonia water, subsequently adding polyethylene glycol and stirring for one hour, pouring the silicon dioxide colloidal solution containing methylthionine chloride into the solution, stirring for 3 hours, centrifuging, washing and drying the solution to obtain the silicon dioxide / octacalcium phosphate particles capable of releasing the methylthionine chloride monomers. The method is simple in process and low in costs of raw materials; the industrial production is easy to be implemented; the particles prepared by the method have good compatibility and are easy to be degraded; the methylthionine chloride is released from the particles in the form of monomer molecules into the solution; meanwhile, the releasing behavior is convenient to control.

Description

Technical field [0001] The invention provides a preparation method of silica / octacalcium phosphate particles releasing methylene blue monomer, which belongs to the technical field of chemical raw material production. Background technique [0002] Methylene blue can treat diseases such as malaria and urinary tract infections. It is widely used in photochemotherapy and other fields. It also has a significant effect on inhibiting the accumulation of Tau protein in the treatment of Alzheimer's disease. Therefore, it has attracted wide attention from researchers. Methylene blue molecules exist in the form of monomers and dimers in the solution, and the aggregation form of the molecules has a significant impact on the photochemotherapy effect, redox performance and cell membrane spanning ability. Compared with the methylene blue dimer, the methylene blue monomer transitions to an excited state under light excitation conditions, and the excess energy is absorbed by oxygen molecules duri...

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Problems solved by technology

To solve the above problems, researchers (S. Zhang, Z. Chu, C. Yin, C. Zhang, G. Lin, Q. Li, J. Am. Chem. Soc. 2013, 135, 5709-5716) adopted the The method of encapsulating methylene blue molecules in the drug carrier can ensure the sustained release of methylene blue molecules and prolong the action time of methylene blue in the body, but there are no reports on the related research that methylene blue mainly exists in the form of monomers in the solution

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