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acceleration sensitive indicator

An indicator and acceleration technology, applied in the direction of acceleration measurement using inertial force, fluid controller, laboratory equipment, etc., can solve the problem of indistinguishability

Active Publication Date: 2019-07-05
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the upper part of a blood sample naturally becomes transparent when sitting in an upright orientation, the light detector cannot reliably distinguish between a properly centrifuged sample and a plasma sample with a naturally occurring pellet

Method used

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Examples

Experimental program
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Embodiment Construction

[0101] figure 1 An example of an acceleration sensitive indicator 1 is schematically shown for indicating the centrifugation state of a biological sample. The indicator 1 comprises a closed chamber 2 comprising an indication area 3 . The indication zone 3 comprises two adjacent fluid transfer zones 4 , 5 separated by a fluid barrier 6 . The fluid transfer zones 4, 5 include readable codes 7, 8, respectively.

[0102] Figure 2a is through the line AA' figure 1 A schematic but not to scale cross-sectional view of the acceleration-sensitive indicator 1. In particular, the indicator 1 comprises a cover layer 9 from top to bottom, a spacer layer 10, a backing layer 11 and an adhesive layer 12 for attaching the indicator 1 to the wall of the sample container, wherein the chamber 2 is formed between the cover layer 9 and the backing layer 11. Between the backing layer 11. In more detail, the cover layer 9 is made of transparent polyethylene terephthalate (PET) and includes an ...

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Abstract

Disclosed is an acceleration-sensitive indicator for indicating the centrifugation state of a biological sample; a sample container including the acceleration-sensitive indicator; a centrifuge for centrifuging the sample container; and an analysis system for analyzing centrifuged sample. The indicator includes at least one closed chamber formed between two opposing surfaces. The chamber comprises at least one indication zone comprising at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises at least one solid support phase and at least one fluid stabilized in the solid support phase, or at least one non-stabilized non-Newtonian fluid having thixotropic and / or shear thinning properties. The at least one particle transfer zone includes at least one particle stabilization fluid comprising stabilized dispersed particles.

Description

technical field [0001] The present invention relates to an acceleration sensitive indicator for indicating the application of an acceleration field; a sample container comprising the indicator for centrifuging a biological sample contained therein; and an analysis system for determining The centrifugation state of the sample. Background technique [0002] Proper analysis of biological samples may depend on the centrifugation state of the biological sample, so it is often important to determine whether the centrifugation step to separate the various sample components has been completed. Not only the lack of a complete centrifugation step may affect the validity of the analytical test, but additional unnecessary centrifugation steps applied to a sample may negatively affect the quality of the analysis performed on that sample. For example, many sample tubes used to prepare plasma or serum from whole blood samples include a gel to stably hold the sediment (which may contain pe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/14
CPCB01L3/5021B01L3/5453B01L2200/14B01L2200/143B01L2300/021B01L2300/025B01L2300/0663B01L2400/0409G01P15/02
Inventor G.伯格哈特M.格劳瑟O.古特曼D.米勒E.奥斯特布罗尔克R.桑多兹E.萨罗菲姆G.萨瓦迪克
Owner F HOFFMANN LA ROCHE & CO AG
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