Injection for treating pyrexia and hoof disease of dairy cows, and its preparation method

A technology for injection and hoof disease, applied in the directions of antipyretics, pharmaceutical formulations, non-central analgesics, etc., can solve problems such as the application of diclofenac sodium injection, and is suitable for large-scale industrial production, low production cost, and easy to prepare Simple and convenient process

Inactive Publication Date: 2015-01-21
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no unilateral diclofenac sodium injection used in veterinary clinical

Method used

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  • Injection for treating pyrexia and hoof disease of dairy cows, and its preparation method
  • Injection for treating pyrexia and hoof disease of dairy cows, and its preparation method
  • Injection for treating pyrexia and hoof disease of dairy cows, and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The injection used to treat fever and lameness in dairy cows in this example consists of the following components per 100 mL of injection: 2 g of diclofenac sodium, 0.1 g of anhydrous sodium sulfite, 0.01 g of disodium edetate, 1,2- Propylene glycol 10mL, polyethylene glycol-400 10mL, and the balance water for injection.

[0029] The preparation method for the injection that is used for the treatment of milk cow heating and lameness in the present embodiment comprises the following steps:

[0030] (1) Precisely measure and mix 10mL of 1,2-propanediol and 10mL of polyethylene glycol-400, and add 10mL of water for injection at the same time, place it on a magnetic stirrer, stir and heat to 40°C;

[0031] (2) Dissolve 0.1g of anhydrous sodium sulfite and 0.01g of EDTA-2Na in 10mL of water for injection at 40°C, mix well, and set aside;

[0032] (3) Get two kinds of solutions in step (1), (2) and mix, constantly stir and heat;

[0033] (4) When the temperature of the mixt...

Embodiment 2

[0037] In this example, the injection used to treat fever and hoof disease in dairy cows consists of the following components per 100 mL of injection: 5 g of diclofenac sodium, 0.3 g of anhydrous sodium sulfite, 0.02 g of disodium edetate, 1,2 - Propylene glycol 35mL, the balance is water for injection.

[0038] The preparation method for the injection that is used for the treatment of milk cow heating and lameness in the present embodiment comprises the following steps:

[0039] (1) Accurately measure 35mL of 1,2-propanediol, add 10mL of water for injection, place on a magnetic stirrer, stir and heat to 45°C;

[0040] (2) Dissolve 0.3g of anhydrous sodium sulfite and 0.02g of EDTA-2Na in 10mL of water for injection at 45°C, mix well, and set aside;

[0041] (3) Get two kinds of solutions in step (1), (2) and mix, constantly stir and heat;

[0042] (4) When the temperature of the mixed liquid in step (3) is heated to 50°C, add 5 g of diclofenac sodium, and at the same time c...

Embodiment 3

[0046] The injection used to treat fever and hoof disease in dairy cows in this example consists of the following components per 100 mL of injection: 8 g of diclofenac sodium, 0.4 g of anhydrous sodium sulfite, 0.03 g of disodium ethylenediaminetetraacetate, polyethylene glycol Alcohol-40055mL, the balance is water for injection.

[0047] The preparation method for the injection that is used for the treatment of milk cow heating and lameness in the present embodiment comprises the following steps:

[0048] (1) Accurately measure 55mL of polyethylene glycol-400, add 10mL of water for injection, place on a magnetic stirrer, stir and heat to 35°C;

[0049] (2) Dissolve 0.4g of anhydrous sodium sulfite and 0.03g of EDTA-2Na in 10mL of water for injection at 35°C, mix well, and set aside;

[0050] (3) Get two kinds of solutions in step (1), (2) and mix, constantly stir and heat;

[0051] (4) When the temperature of the mixed solution in step (3) is heated to 60°C, add 8g of diclo...

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Abstract

The invention discloses an injection for treating pyrexia and the hoof disease of dairy cows, and its preparation method, and belongs to the technical field of veterinary western medicines. Every 100 ml of the injection is composed of 2-10g of diclofenac sodium, 0.1-0.5g of an antioxidant, 0.01-0.05g of a stabilizer, 20-80 ml of a cosolvent, and the balance of water for injection. The injection meets the veterinary drug market's demands on new antipyretic analgesic drugs, and has the advantages of good curative effect, small side effects and no accumulation in the clinical use process. Propylene glycol or polyethylene glycol-400 adopted as a cosolvent and the stabilizer disodium ethylenediaminetetraacetate synergistically enhance the dissolvability of diclofenac sodium in water, so the stability of the injection is increased. Anhydrous sodium sulfite has a stable anti-oxidation effect in alkaline environment with the pH value of 7.5-9.0. The preparation method of the diclofenac sodium injection has the advantages of simple and convenient preparation, low production cost, and suitableness for large-scale industrial production.

Description

technical field [0001] The invention relates to an injection for treating fever and hoof disease of dairy cows and a preparation method of the injection, belonging to the technical field of veterinary western medicine. Background technique [0002] Fever and hoof disease in dairy cows are common diseases, which seriously affect the development of dairy farming industry. Common types of hoof disease include longitudinal and transverse cracks, dermatitis, cellulitis, and laminitis. The cowshed is humid, the environment is poor, the ground is hard, the playground is uneven, there is water all year round, there are sharp objects or hard edges and corners, it is easy to cause hoof disease. In addition, various cow diseases can cause febrile symptoms. At present, there is an urgent need for an antipyretic and analgesic dosage form that is specially used for dairy cows, has good curative effect, little side effects, and no accumulation, and is used for treating fever and hoof dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/196A61K47/34A61K47/10A61P29/00
Inventor 郭玉凡王佳伟杜丹丹王颖周衡陈盟
Owner ZHENGZHOU BARY ANIMAL PHARMA
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