Microneedle drug delivery device and method of making the same

Abstract

The invention discloses a microneedle doser and a manufacturing method thereof. The microneedle doser comprises a microneedle substrate, a medicine cavity and a piezoelectric element, wherein the microneedle substrate is provided with a first surface and a second surface, and comprises a solid microneedle array on the first surface and a micropore array which penetrates a first substrate and protrudes from the first surface to the second surface; the medicine cavity comprises an inner space exposed on the first surface and a second surface opposite to the bottom of the inner space, wherein the second surface of the microneedle substrate is combined with the first surface of the medicine cavity so as to enclose the inner space; the piezoelectric element is combined with the second surface of the medicine cavity, wherein the microneedle substrate and the medicine cavity are formed an MEMS (Micro-electromechanical Systems) sensor. According to the microneedle doser, the solid microneedle can be used for working continuously and efficiently, and the MEMS sensor can be used for realizing the precise and quantitative control.

Description

technical field [0001] The present invention relates to a drug delivery device and method, in particular, to a microneedle drug delivery device and a manufacturing method thereof. Background technique [0002] The main delivery methods of drugs into the human body include injection and oral administration. In recent years, microneedle drug delivery has attracted more and more attention. Microneedle is a micron-sized hollow or solid needle similar to an injection needle, made of single crystal silicon material, metal or polymer, with a diameter of 30-80 μm and a length of 100-1000 μm. It can just pass through the stratum corneum without touching the pain-sensing nerve, and it can promote penetration without causing pain and skin damage. [0003] Another existing technology for painless drug delivery is micro-spray drug delivery, in which micro-electro-mechanical system (MEMS) technology is used to process single crystal silicon material into a nano-jet pump. The pressure i...

AI Technical Summary

Problems solved by technology

After one use, it can be discarded or applied again after disinfection, which is very cumbersome and inconvenient to operate, and continuous and controllable drug administration cannot be achieved.

[0005] When using hollow microneedles, although the purpose of quantitative injection and multiple use can be achieved, the process of processing tiny needles (30-80 microns in diameter) into hollow needle tubes is difficult and the yield rate is low

Because the needle is very fine, the hollow structure is easy to break and block, resulting in the need for frequent replacement

[0006] When micro-spray is used for drug delivery, the drug liquid can only be sprayed to the designated position, and it is used for oral or skin external use. The drug still needs to be absorbed through the mucous membrane or through the skin, and the drug absorption rate is much lower than that of injection or microneedle penetration. skin administration

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