Amoxicillin and clavulanate potassium flavor tablet for pets

A technology of amoxicillin-clavulanate potassium and amoxicillin, which is applied in the field of amoxicillin-clavulanate potassium flavor tablets for pets and its preparation, and can solve the problems of drugs entering the trachea by mistake, foreign body pneumonia, pet doctors and animal owners' injuries and other problems, to achieve the effect of improving the tableting process, convenient storage, and convenient administration

Inactive Publication Date: 2015-02-11
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the chewable tablet needs to be manually put into the animal's mouth, which is easy to cause injury to the veterinarian or the animal owner in the clinical operation, and it is easy to cause the drug to enter the trachea by mistake, causing foreign body pneumonia in the sick animal

Method used

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  • Amoxicillin and clavulanate potassium flavor tablet for pets
  • Amoxicillin and clavulanate potassium flavor tablet for pets
  • Amoxicillin and clavulanate potassium flavor tablet for pets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Party:

[0020]

[0021] Preparation:

[0022] A. Amoxicillin is granulated by roller extrusion dry method, crushed into particles with a particle diameter of 1 mm, mixed with potassium clavulanate at a mass ratio of 4:1 to form the main ingredient; the detailed preparation process should be write clearly

[0023] B. The auxiliary materials magnesium stearate, micropowder silica gel, croscarmellose sodium, microcrystalline cellulose and flavoring agent are added and mixed in equal amounts to form an initial mixed sample;

[0024] C. Put the initial mixed sample and the main material into the mixer and mix them evenly to make a total mixed sample, and the water content is controlled between 2-6%;

[0025] D. The mixed sample is compressed into tablets, each tablet contains 50 mg of amoxicillin and 12.5 mg of potassium clavulanate.

Embodiment 2

[0027] Party:

[0028]

[0029] Preparation:

[0030] A. Amoxicillin is granulated by roller extrusion dry method, broken into particles with a particle diameter of 1mm, mixed with potassium clavulanate at a mass ratio of 4:1 to form a main ingredient;

[0031] B. The auxiliary materials magnesium stearate, micropowder silica gel, croscarmellose sodium, microcrystalline cellulose and flavoring agent are added and mixed in equal amounts to form an initial mixed sample;

[0032] C. Put the initial mixed sample and the main material into the mixer and mix them evenly to make a total mixed sample, and the water content is controlled between 2-6%;

[0033] D. The mixed sample is compressed into tablets, and each tablet contains 100 mg of amoxicillin and 25 mg of potassium clavulanate.

Embodiment 3

[0035] Party:

[0036]

[0037] Preparation:

[0038] A. Amoxicillin is granulated by roller extrusion dry method, broken into particles with a particle diameter of 1mm, mixed with potassium clavulanate at a mass ratio of 4:1 to form a main ingredient;

[0039] B. The auxiliary materials magnesium stearate, micropowder silica gel, croscarmellose sodium, microcrystalline cellulose and flavoring agent are added and mixed in equal amounts to form an initial mixed sample;

[0040] C. Put the initial mixed sample and the main material into the mixer and mix them evenly to make a total mixed sample, and the water content is controlled between 2-6%;

[0041] D. The mixed sample is compressed into tablets, and each tablet contains 20 mg of amoxicillin and 5 mg of potassium clavulanate.

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Abstract

The invention discloses an amoxicillin and clavulanate potassium flavor tablet for pets, and its preparation technology. The flavor tablet comprises 8-40% of amoxicillin, 2-10% of clavulanate potassium, 30-80% of microcrystalline cellulose, 0.5-4% of cross-linked carboxymethyl cellulose sodium, 0.5-2% of aerosil, 0.5-4% of magnesium stearate and 1-15% of a flavoring agent. The amoxicillin and clavulanate potassium flavor tablet prepared in the invention is a tablet specially designed for solving the palatability of pets, can satisfy taste demands of the majority of pets, and has the characteristics of convenient administration, rapid action, high blood concentration and stable curative effect.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a flavored amoxicillin-clavulanate potassium tablet for pets and a preparation method thereof. Background technique [0002] Amoxicillin and Potassium Clavulanate Flavored Tablets for Pets is a compound preparation composed of Amoxicillin and Potassium Clavulanate. Among them, amoxicillin is a broad-spectrum penicillin antibiotic, and potassium clavulanate itself has only weak antibacterial activity, but has a strong β-lactamase inhibitory effect. The combination of the two can protect amoxicillin from β-lactamase hydrolysis. In vitro antibacterial studies have shown that clavulanic acid can increase the antibacterial activity of amoxicillin against Klebsiella vulgaris Proteus and a small number of intestinal enzyme-producing bacteria by 4-32 times, and increase the antibacterial activity against Haemophilus influenzae by 32 times. Amoxicillin has 4-32 times the anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61K9/20A61K47/46A61P31/04A61K31/424
CPCA61K31/43A61K9/2068A61K31/424A61K2300/00
Inventor 魏德宝王爱萍徐晓然
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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