Pharmaceutical composition for restraining tumors

A composition and tumor technology, which can be used in drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., and can solve problems such as unreported anti-tumor effects.

Active Publication Date: 2015-02-11
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Currently, TMZ and 20(S)-G-Rh 2 Studies on the an...

Method used

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  • Pharmaceutical composition for restraining tumors
  • Pharmaceutical composition for restraining tumors
  • Pharmaceutical composition for restraining tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Embodiment 1, the pharmaceutical composition of different proportions

[0116] Composition and its preparation:

[0117] Ginsenoside Rh 2 And the composition of temozolomide, its weight ratio is 1:0.25, and its preparation method is, two kinds of medicines are fully mixed and get final product.

[0118] Composition and its preparation:

[0119] Ginsenoside Rh 2 The composition of Temozolomide and Temozolomide, its weight ratio is 1:8, and its preparation method is, fully mix two kinds of medicines and get final product.

[0120] Composition and its preparation:

[0121] Ginsenoside Rh 2 The composition of Temozolomide and Temozolomide has a weight ratio of 1:1, and the preparation method is as follows: fully mixing the two medicines evenly.

[0122] Composition and its preparation:

[0123] Ginsenoside Rh 2 The composition of Temozolomide and Temozolomide, its weight ratio is 1:2, and its preparation method is, fully mix two medicines and get final product.

Embodiment 2

[0125] tablet

[0126] 【prescription】

[0127] Any composition 100g of embodiment 1

[0128] Microcrystalline cellulose 50g

[0129] Micropowder silica gel 3g

[0130] Magnesium stearate 1.5g

[0131] [Preparation method] Get the original and auxiliary materials and pass through a 100-mesh sieve respectively; take any composition and microcrystalline cellulose of Example 1, mix well, use 60% ethanol in an appropriate amount as a binder to make a soft material, and pass through a 20-mesh sieve Make granules, dry at 60°C, take out, sieve through a 30-mesh sieve for granulation, add micropowder silica gel and magnesium stearate, mix well, press into tablets, and make 1000 pieces, that is, ready.

Embodiment 3

[0133] 【prescription】

[0134] Any one composition 75g of embodiment 1

[0135] Microcrystalline cellulose 37g

[0136] Micropowder silica gel 2.3g

[0137] Magnesium stearate 1.1g

[0138] [Preparation method] Get the original and auxiliary materials and pass through a 100-mesh sieve respectively; take any composition and microcrystalline cellulose of Example 1, mix well, use 60% ethanol in an appropriate amount as a binder to make a soft material, and pass through a 20-mesh sieve Make granules, dry at 60°C, take them out, pass through a 30-mesh sieve for granulation, add appropriate amount of micropowder silica gel and magnesium stearate, mix well, and press into tablets.

[0139] Make 1000 pieces, that is.

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PUM

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Abstract

The invention relates to a pharmaceutical preparation, in particular to a compound pharmaceutical preparation with ginsenoside Rh2 and temozolomide as medicine active ingredients.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation, in particular to a compound pharmaceutical preparation with ginsenoside Rh2 and temozolomide as active ingredients. Background technique: [0002] Temozolomide (TMZ) is a marketed antineoplastic drug with the chemical name 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3 , 5-tetrazine-8-amide, the structural formula is as follows: [0003] [0004] Temozolomide is mainly used for the treatment of refractory glioblastoma multiforme and recurrent or progressive glioblastoma multiforme or anaplastic astrocytoma in adults. Through the blood-brain barrier, the main anti-tumor mechanism is the cytotoxicity produced by the failure of DNA methylation and mismatch repair, but the anti-tumor spectrum is narrow, there is drug resistance, and adverse reactions will occur. [0005] Ginsenoside Rh 2 (ginsenoside Rh 2 , G-Rh 2 ) [alias] 20(S)-ginsenoside Rh 2 , [chemical name] protopanaxadiol-3-oxo-B-D-gl...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P35/00A61K31/4188
CPCA61K31/4188A61K31/704A61K2300/00
Inventor 马晓慧张兰兰颜璐璐李秋颖张莉华李德馨王晶曹晶宋兆辉王国成周水平郭治昕朱永宏
Owner TIANJIN TASLY PHARMA CO LTD
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