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Preparation method and application of au-doped titanium dioxide nanotubes modified by hyaluronic acid

A technology of hyaluronic acid modification and titanium dioxide, which is applied in the field of medicine, can solve the problems of no public reports of Au-doped titanium dioxide nanotubes, and achieve the effect of simple synthesis process, excellent photothermal conversion characteristics, and low toxicity

Inactive Publication Date: 2017-04-12
ZHENGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far there is no public report on Au-doped titania nanotubes modified with hyaluronic acid and its application

Method used

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Embodiment Construction

[0014] The specific implementation of the present invention will be described in detail below in conjunction with the examples.

[0015] In specific implementation, the present invention can also be realized by the following steps:

[0016] (1) Synthesis of titanium dioxide nanotubes: Weigh 40g NaOH into a beaker, add deionized water, stir in an ice bath to dissolve, cool to room temperature, add deionized water to 100ml, add 200mg TiO 2 Nanoparticle powder, ultrasonically dispersed for 15 minutes, placed in a polytetrafluoroethylene liner reactor, heated in a muffle furnace at 150°C for 24-35 hours, cooled to room temperature, washed with 0.1mol / L HCl solution and deionized water in sequence To pH 7, filter with a microporous membrane (water membrane) with a diameter of 0.22 μm, dry in a vacuum oven at 60°C, grind to obtain titanium dioxide nanotubes (TiNTs), and store in the dark;

[0017] (2) Preparation of Au-doped titania nanotubes: Weigh 200 mg of chloroauric acid solid...

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Abstract

The invention relates to a preparation method and an application of a hyaluronic acid modified Au-doped titanium dioxide nano-tube, and is used for effectively solving the problems of the preparation of the hyaluronic acid modified Au-doped titanium dioxide nano-tube and the application in preparing medicaments for treating tumors. The preparation method comprises the following steps: preparing a titanium dioxide nano-tube by virtue of a hydrothermal synthesis process, then preparing a titanium dioxide nano-tube with Au modified on the surface by using the titanium dioxide nano-tube as a precursor by virtue of an illumination reductive calcination process, connecting mercaptoacetic acid to the Au-doped titanium dioxide nano-tube by virtue of thiol gold bonds, and performing covalent linkage on hyaluronic acid and mercaptoacetic acid modified on the surface of Au-doped titanium dioxide nano-tube by using alkylene diamine as a connecting arm to form a nano layer in an aqueous medium, wherein the molecular weight of hyaluronic acid is more than or equal to 600 daltons and less than or equal to 400kd, and the connecting arm is an alkylene diamine structure with 2-12 carbon atoms. The hyaluronic acid modified Au-doped titanium dioxide nano-tube is strong in targeting performance, and can be used for achieving comprehensive therapies of cancers more effectively by combining photodynamic therapy, photothermal therapy and chemotherapy together.

Description

technical field [0001] The invention relates to medicine, in particular to a preparation method and application of hyaluronic acid-modified Au-doped titanium dioxide nanotubes. Background technique [0002] Malignant tumors have surpassed cardiovascular diseases and become the leading cause of death for urban residents, seriously threatening human life and health. Currently, chemotherapy, radiotherapy and surgery are commonly used in medicine to treat cancer. Chemotherapy uses drugs to destroy cancer cells, but there are problems of poor targeting and dose-limiting toxicity; radiotherapy uses ionizing radiation to kill cancer cells and shrink tumors, but normal tissues will also receive corresponding benefits during clinical treatment. Radiation damage; surgery is to achieve the purpose of treating cancer by removing tumor tissue, but it is more traumatic to the human body, and the curative effect is often poor because the cancer cells have spread. Therefore, with the cont...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61K47/02A61K47/36A61K41/00A61P35/00
Inventor 张振中张慧娟郭冀民陈倩倩冀嫣丹焦晓静侯琳张红岭
Owner ZHENGZHOU UNIV
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