Pre-eclampsia screening methods

A technology for pre-eclampsia and eclampsia, applied in the field of pre-eclampsia screening method, can solve problems such as the degree of onset of the disease

Active Publication Date: 2015-02-25
SIEMENS HEALTHCARE DIAGNOSTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Also, many previous studies assessed later in the first trimester, which also affects how well certain measures predict the onset of the condition

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] The following studies were performed to develop a logistic regression based predictive model for early-onset and late-onset preeclampsia.

[0076] Methods and Patients

[0077] A prospective cohort of singleton pregnancies underwent routine first-trimester screening at the Department of Maternal-Fetal Medicine of the Hospital Clinic Barcelona. The local ethics committee approved the study protocol and each patient provided written informed consent. Gestational age was calculated in all pregnancies based on crest-rump length (CRL) measured on first-trimester ultrasound. Maternal characteristics and medical history were recorded and blood pressure, UtA, and plasma concentrations of PAPP-A and fβ-HCG were measured in the first trimester.

[0078] Between May 2007 and October 2009, a total of 5,759 women were examined. Among these participants, a total of 589 (10.2%) were excluded for the following reasons (non-exclusively): missing outcome data (n=525), severe fetal d...

Embodiment 2

[0112]Patient-specific data were fitted to the model described in Example 1. The model was applied to a 35 year old woman undergoing her first pregnancy with a prothrombin gene mutation but no other conditions. At the time of first trimester ultrasound (CRL: 65 mm), the patient was 165 cm tall and weighed 65 kg (BMI 23.8 kg / m 2 ). The patient had a mean UtA-PI of 1.85, a MAP of 90 mmHg, and a PAPPA-P of 0.87 MoM. The following results are based on data obtained from this patient. the

[0113] The expected log average UtA-PI is: 0.668018 - (0.002772 * 65) - (0.001536 * 165) - (0.001151 * 35) = 0.194

[0114] The log MoM average UtA PI is: log(1.85) - 0.194 = 0.073

[0115] The expected log MAP is: 1.803485 + (0.00299 * 23.8) + (0.000645 * 35) = 1.897

[0116] The log MoM MAP is: log(90) - 1.897 = 0.057

[0117] The prior probability of early-onset PE is: Y = -5.617

[0118] a priori risk = e -5.617 / (1+e -5.617 ) = 0.0036

[0119] The posterior probability of early...

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Abstract

The present invention relates generally to methods for treating early and late onset pre-eclampsia, as well as to methods of screening for and predicting the likelihood that a pregnant female patient will develop early and / or late pre-eclampsia, by assessing specific combinations of factors. In the methods of the invention, the a priori risk of developing eariy preeclampsia may be calculated utilizing coefficients for each of the maternal factors (binary variables), the coefficients being generated utilizing logistic regression analysis. The a posteriori risk of developing eariy pre-eclampsia may be calculated utilizing coefficients for each of the patient-specific factors, the coefficients being generated utilizing logistic regression analysis.

Description

[0001] This application claims priority to US Provisional Patent Application No. 61 / 637,637, entitled "Solution on pre-eclampsia screening on general population of pregnant women," filed April 24, 2012, which is hereby incorporated by reference in its entirety. field of invention [0002] The present invention generally relates to methods of treating early-onset and late-onset preeclampsia and methods of screening and predicting the likelihood of early-onset and / or late-onset preeclampsia in pregnant patients by evaluating specific combinations of factors. Background of the invention [0003] Preeclampsia (PE) occurs in approximately 2-3% of pregnancies. In developed countries, PE is the leading cause of maternal admission to the intensive care unit and accounts for approximately 15% of all pregnancy-related deaths. In addition, PE is associated with an increased risk of perinatal mortality and is responsible for approximately 10% of stillbirths and 15% of preterm births. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50
CPCG01N2800/50G01N2800/368G01N33/689G01N33/76A61B5/0205A61B5/021A61B5/024A61B5/14546A61B5/4325A61B5/4362A61B5/4839A61B5/486A61B5/4872A61B5/7225A61B5/7275A61K45/06
Inventor E.格拉塔科斯F.菲盖拉斯F.克里斯皮L.拉萨维亚J.米南
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC
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