Application of miRNA‑27b in antitumor drug resistance

A miRNA-27b, tumor technology, applied in the field of biotechnology and medicine, can solve problems such as unclear miRNA personalized treatment
CN104415347BActive Publication Date: 2017-11-10CENT FOR EXCELLENCE IN MOLECULAR CELL SCI CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CENT FOR EXCELLENCE IN MOLECULAR CELL SCI CHINESE ACAD OF SCI
Publication Date
2017-11-10

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Abstract

The present invention relates to the application of miRNA-27b in anti-tumor drug resistance. Specifically, the present invention studies tumor tissues of tumor patients and conducts large-scale screening of human miRNA libraries through high-throughput microRNA chips. Among a large number of microRNAs, it is found that miR-27b is generally down-regulated in tumors, and miR-27b family members It can improve the sensitivity of tumor cells to anti-tumor drugs. The present invention also finds that miR-27b targets genes such as p53 and CYP1B1 in the tumor drug resistance signaling pathway; promoting p53 and inhibiting CYP1B1 expression can improve the sensitivity of tumors to anti-tumor drugs.
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Description

technical field

[0001] The invention belongs to the fields of biotechnology and medicine, in particular, the invention relates to microRNAs related to anti-tumor drug resistance and applications thereof. Background technique

[0002] The use of antitumor drugs is an important option for tumor treatment, especially for advanced tumors that cannot be surgically removed. However, clinical studies have shown that the resistance of tumor cells to drugs is the main reason for drug failure, especially for two types of solid tumors, liver cancer and kidney cancer, where drug resistance is particularly serious. Sorafenib is one of the most effective target-specific drugs. One, it can only temporarily prolong the patient's survival time by three months. Moreover, once tumor cells develop resistance to a certain drug, they often develop resistance to other structurally and functionally irrelevant drugs. This phenomenon of multidrug resistance suggests that tumor cells may adopt some ...

Claims

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