Combined marker for early diagnosis of liver cancer and its application

A marker and liver cancer technology, applied in the field of biomedicine, can solve the problems of lack of effective therapeutic targets, difficulties in early diagnosis, high recurrence and metastasis rate, and achieve the effect of avoiding tissue biopsy, improving early screening sensitivity, and improving sensitivity
CN113337608BActive Publication Date: 2022-08-02CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
Publication Date
2022-08-02

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Abstract

The invention discloses a combined marker for early diagnosis of liver cancer and its application. The combined markers for early diagnosis of liver cancer disclosed in the present invention are FAM78A, MKL1, DCDC2, SR, BCL2L11, CYP1B1, PTPN7, AXIN1, SEMA4D, PROX1, SHH, AK055957, DAB2IP, TBX15, GRASP, PPFIA1 and / or PSD4. Methylation, and mutation of TERT and / or CTNNB1. The present invention performs liver cancer detection by detecting the methylation level of the gene combination in the plasma cfDNA, and has high sensitivity and specificity; in the case of adding the mutation detection of the gene, by simultaneously detecting the methylation of the gene combination and the TERT gene , CTNNB1 gene mutation, effectively improve the sensitivity of early screening.
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Description

technical field

[0001] The invention relates to a combined marker for early diagnosis of liver cancer and its application in the field of biomedicine. Background technique

[0002] Liver cancer is one of the malignant tumors with high incidence and great harm. However, the current diagnosis and treatment of liver cancer still faces major problems: difficulty in early diagnosis, high recurrence and metastasis rate, resistance to radiotherapy and chemotherapy, and lack of effective therapeutic targets. And for any cancer, early screening is always a critical step in the fight against cancer.

[0003] The routine surveillance and screening indicators for the early diagnosis of liver cancer mainly include alpha-fetoprotein (AFP) and liver ultrasonography (US). Based on domestic and foreign reports and clinical practice, the diagnostic sensitivity of AFP is about 60%, the missed diagnosis rate is 40%, the specificity is about 80%, and the misdiagnosis rate is 20%. An important...

Claims

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