Rebamipide monohydrate crystal form and preparation method thereof

A technology of monohydrate and rebamipide, which is applied in the field of crystal form of rebamipide monohydrate and its preparation, can solve the problems affecting the stability, dissolution and bioavailability of preparations, affecting the quality and safety of pharmaceutical preparations issues of sexuality and effectiveness
CN104418802AActive Publication Date: 2015-03-18CHONGQING HUIZHI PHARMA RES INST +1
5 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING HUIZHI PHARMA RES INST
Publication Date
2015-03-18

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a rebamipide monohydrate crystal form and a preparation method thereof. The invention further relates to a pharmaceutical composition taking a rebamipide monohydrate containing the crystal form as an active compound and application of the pharmaceutical composition in manufacturing of medicaments for treating diseases related to gastric ulcer, acute gastritis, chronic gastritis and gastric mucosal injuries caused by acute exacerbation.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of medicinal chemistry, and in particular relates to a crystal form of rebamipide monohydrate and a preparation method thereof, a drug combination containing the crystal form of rebamipide monohydrate as an active ingredient, and its Application in the manufacture of drugs for the treatment of gastric ulcer, acute gastritis, and gastric mucosal injury related diseases caused by acute exacerbation of chronic gastritis. Background technique

[0002] Rebamipide, whose chemical name is 2-(4-chlorobenzamido)-3-[2(1H)-quinolone-4-yl]propionic acid), has the following chemical structure:

[0003]

[0004] Rebamipide was developed by Japan's Otsuka Pharmaceutical Co., Ltd. and was launched in Japan in 1990 as an oral protective anti-ulcer drug for the treatment of gastric ulcer, acute gastritis and gastric mucosal damage caused by acute exacerbation of chronic gastritis.

[0005] Japanese Pharmacopoeia JP16 reco...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More