Preparation method of tributyrin microcapsules

A technology of tributyrin and tributyrin, which is applied in the field of preparation of tributyrin microcapsules, can solve the problems of easy caking, moisture on the surface of the adsorbent, no fluidity, etc., and achieve low production cost, Inexpensive equipment and good compatibility

Active Publication Date: 2017-07-11
曹胜炎 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although tributyrin can play the above two functions at the same time, it is inconvenient to use because tributyrin is liquid
Chinese patent application (Application No. 201410298903.2) "Glyceryl tributyrate solid granular preparation and its preparation method and application" discloses a method for preparing a solid preparation by using white carbon black silica gel to adsorb tributyrin, but using inorganic adsorption There are many defects in the simple adsorption of tributyrin by an inorganic adsorbent: when the inorganic adsorbent adsorbs more tributyrin, the surface of the adsorbent is relatively wet, easy to agglomerate, and has no fluidity; at the same time, due to the high boiling point of tributyrin, it cannot Dried granules are produced using conventional methods such as heat drying, thereby affecting the commercial form of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Add 100kg of stearic acid, 55kg of tributyrin, and 5kg of tripolyglycerin fatty acid ester into a 500L reactor, heat and melt to stabilize the material temperature at 80±5°C;

[0022] 2. Add 1000kg of hot water at 80±5°C to the 2000L reactor, inject the melted oil phase in step 1, and stir for 3~10min to make the oil phase evenly dispersed in the water;

[0023] 3. Weigh 13kg of calcium hydroxide and 100kg of water to form milk of lime, pump it in from the lower part of the reaction kettle and stir, continue to stir for 10 minutes after adding the milk of lime, discharge the material, and filter the water with a 200-mesh filter. The filter cake was dried in a drying room at 50°C for 20-40 hours to obtain 173 kg of tributyrin fatty acid calcium microcapsules, of which the content of tributyrin was 31.8%.

Embodiment 2

[0025] 1. Add 100kg of palmitic acid, 100kg of tributyrin, 2kg of tripolyglycerin fatty acid ester, 2kg of Tween 80 into a 500L reactor, heat and melt to stabilize the material temperature at 80±5°C;

[0026] 2. Add 1300 kg of 80±5°C hot water into the 2000L reactor, inject the melted oil phase in the first step, and stir for 3~10min to make the oil phase evenly dispersed in the water;

[0027] 3. Weigh 15kg of calcium hydroxide and 100kg of water to form milk of lime, pump it in from the lower part of the reaction kettle and stir, continue to stir for 10 minutes after adding the milk of lime, discharge the material, filter the water with a 200-mesh filter, and filter Dry the cake in a drying room at 50°C for 20-40 hours to obtain 220 kg of tributyrin fatty acid calcium microcapsules with a tributyrin content of 45.5%.

Embodiment 3

[0029] 1. Add 100kg of palmitic acid, 70kg of tributyrin, and 5kg of tripolyglycerin fatty acid ester into a 500L reactor, heat and melt to stabilize the material temperature at 80±5°C;

[0030] 2. Add 1000kg of 80±5℃ hot water into the 2000L reactor, pour the melted oil phase in step 1, and stir for 3~10min to make the oil phase evenly dispersed in the water;

[0031] 3. Weigh 15kg of calcium hydroxide and 100kg of water to form milk of lime, pump it in from the lower part of the reaction kettle and stir, continue to stir for 10 minutes after adding the milk of lime, discharge the material, filter the water with a 200-mesh filter, and filter The cake was dried in a drying room at 50°C for 20-40 hours to obtain 190 kg of tributyrin fatty acid calcium microcapsules with a tributyrin content of 36.8%.

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Abstract

The invention discloses a preparation method of tributyrin microcapsules, which is prepared from 100 parts of raw fatty acid, 50-100 parts of tributyrin, 1-10 parts of emulsifier and 13-15 parts of calcium hydroxide Formation: Mix and heat tributyrin, fatty acid and emulsifier to melt, then add it into warm water at 80±5℃ and stir evenly to form an emulsion; dissolve calcium hydroxide in water to make 10~20% Lime emulsion; mixing and stirring the emulsion obtained in the first two steps to react to form solid particles; filtering out the water, and drying the filter cake to form a free-flowing tributyrin microcapsule finished product at room temperature. The invention has the advantages of low production cost, simple process and low equipment cost, which is favorable for industrial production, and the obtained solid particle finished product with flowability is more convenient to use as an animal feed additive.

Description

technical field [0001] The invention relates to an animal feed additive, in particular to a preparation method of tributyrin microcapsules. Background technique [0002] Butyric acid is of great significance to the intestinal nutrition of animals. ① It is not only the main source of energy for animal colon cells, but also the substrate for the synthesis of lipids in cell membranes. It plays a role in promoting the growth of digestive tract cells, inducing cell differentiation, affecting gene expression, and inducing important role in apoptosis. ②Butyric acid can reduce the pH value of the intestinal environment and inhibit the growth of harmful bacteria. Therefore, in the feed industry, butyric acid and its salts are widely used as a multifunctional feed additive. However, because butyric acid is liquid at normal temperature and has an extremely unpleasant smell, it is very inconvenient to use, so it is generally used as butyrate such as sodium butyrate or calcium butyrate....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K20/158
Inventor 曹胜炎王宏雁
Owner 曹胜炎
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