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Bamboo leaf flavonoid composite liposome, preparation method and application thereof

A technology of bamboo leaf flavonoids and compound lipids, which can be used in pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of limiting efficacy expression, wide application, difficult skin absorption, and low bioavailability, and achieve enhancement and prolongation. Beauty repair, stable product quality, and the effect of repairing skin nutrition metabolism

Active Publication Date: 2015-04-22
烟台新时代健康产业日化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, in the application of bamboo leaf flavonoids in the field of skin care, most of them are directly added and used. Factors such as light, heat, oxygen in the environment, metal ions and pH value in the system seriously affect its stability.
At the same time, bamboo leaf flavonoids also have problems such as easy oxidation, low water solubility, difficult skin absorption and low bioavailability, which limit the wide application of its efficacy expression and formulation development.

Method used

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  • Bamboo leaf flavonoid composite liposome, preparation method and application thereof
  • Bamboo leaf flavonoid composite liposome, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) Weigh 0.1g bamboo leaf flavonoids (wherein the total flavonoid mass fraction is 24%), 0.2g egg yolk lecithin, 0.02g stigmasterol, 0.01g vitamin C, mix well, dissolve in 100g absolute ethanol, 40°C water bath condition Fully stir to dissolve completely, be incubated 10min, obtain mixed solution I;

[0040] 2) Weigh 0.1g of potassium hyaluronate and 0.1g of polyethylene glycol 4000, mix well, dissolve in 80g of deionized water, fully stir until completely dissolved, stir and heat up to 40°C, and keep warm for 10min to obtain mixed solution II;

[0041] 3) Slowly inject the mixed solution I obtained in step 1) into the mixed solution II obtained in step 2), stir and mix evenly to obtain a composite liposome suspension solution, evacuate to -0.06MPa, stir at 40°C, and remove The ethanol in the solution is stirred evenly to make a primary emulsion;

[0042] 4) Transfer the primary emulsion obtained in step 3) to a high-pressure homogenizer, and perform a homogenization cyc...

Embodiment 2

[0044] 1) Weigh 2.0g bamboo leaf flavonoids (wherein the total flavonoid mass fraction is 40%), 2.0g egg yolk lecithin, 3.0g hydrogenated lecithin, 0.5g stigmasterol, 0.1g superoxide dismutase, mix well, dissolve in 100g of absolute ethanol, fully stirred in a 45°C water bath until completely dissolved, incubated for 10min, and mixed solution I;

[0045] 2) Weigh 2.0g of sodium hyaluronate, 1.0g of polyethylene glycol 4000, and 1.0g of Tween 80, mix well, dissolve in 120g of deionized water, fully stir until completely dissolved, stir and heat up to 45°C, keep warm for 10min, to obtain mixed solution II;

[0046] 3) Slowly inject the mixed solution I obtained in step 1) into the mixed solution II obtained in step 2), stir and mix evenly to obtain a composite liposome suspension solution, evacuate to -0.06MPa, stir at 45°C, and remove the solution The ethanol in the mixture is stirred evenly to make a primary emulsion;

[0047] 4) Transfer the primary emulsion obtained in ste...

Embodiment 3

[0049] 1) Weigh 1.0g bamboo leaf flavonoids (wherein the mass fraction of total flavonoids is 65%), 2.0g soybean lecithin, 0.2g cholesterol, 0.01g vitamin E, mix well, dissolve in 100g absolute ethanol, and have sufficient water bath conditions at 42°C. Stir to dissolve completely, be incubated 10min, obtain mixed solution I;

[0050] 2) Weigh 1.0g of hyaluronic acid and 2.0g of Tween 80, mix well, dissolve in 100g of deionized water, fully stir until completely dissolved, stir to be warmed up to 42°C, and be incubated for 10min to obtain Mixed Solution II;

[0051] 3) Slowly inject the mixed solution I obtained in step 1) into the mixed solution II obtained in step 2, stir and mix evenly to obtain a composite liposome suspension solution, vacuumize to -0.06MPa, stir at 42 ° C, remove the solution ethanol, and stir to make a primary emulsion;

[0052] 4) Transfer the initial emulsion obtained in step 3) to a high-pressure homogenizer, carry out a homogenization cycle treatmen...

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Abstract

The invention relates to a bamboo leaf flavonoid composite liposome and its preparation method and application. The bamboo leaf flavonoid composite liposome contains ingredients according to the following weight ratio of bamboo leaf flavonoid to a complex agent to a membrane material to a propping agent to an antioxidant to a solubilizer being 0.1-2:0.1-2:0.2-5:0.02-0.5:0.01-0.1:0.1-2. By effectively coating bamboo leaf flavonoid, stability and integrity of the functional component are protected. Hyaluronic acid with an outstanding moisturizing effect is compounded during the coating process. Thus, system compatibility of the prepared bamboo leaf flavonoid composite liposome in the development of skin care products is enhanced. Meanwhile, unique carrying capacity and slow release capability of the liposome can promote absorption and long-acting care of the bamboo leaf flavonoid composite liposome in the skin, and effects of skin miniature retention, sun protection, whitening, antisenescence and the like are enhanced.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a bamboo leaf flavonoid complex liposome, a preparation method and an application thereof. Background technique [0002] Bamboo has a profound and unique cultural connotation in my country, and has a relatively long history of edible and medicinal use. In 1998, the Ministry of Health officially promulgated the bamboo leaf as a natural resource of the same origin as medicine and food. With the development of modern science, people's research on bamboo leaves has gradually deepened. Bamboo leaves are rich in flavonoids, phenolic acids, alkaloids, lactones, terpenes, polysaccharides and amino acids, which are beneficial active ingredients needed by the human body. Bamboo leaf flavonoids are a newly developed plant flavonoid preparation with an average content of more than 2%, mainly flavonoid glycosides, which have excellent biological effects such as anti-free radical, antioxidant, anti-i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/73A61K8/14A61Q19/00A61Q17/04A61Q19/02A61Q19/08
Inventor 毕利顺邹鹏飞魏星杨建召唐文金卢伟超
Owner 烟台新时代健康产业日化有限公司
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