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External composition for treating skin diseases

A composition and technology for skin diseases, applied in the field of compositions for external application of skin diseases, can solve problems such as inability to treat skin diseases quickly and in time, and achieve the effects of no recurrence, quick effect and reduced usage

Active Publication Date: 2015-04-29
BEIJING BEIDA MINGDE CHEM PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, external ointments, sprays, liniments, and smears with only a single antifungal active ingredient cannot quickly and timely treat skin diseases with bacterial and fungal co-infection

Method used

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  • External composition for treating skin diseases
  • External composition for treating skin diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The povidone-iodine-containing composition for external treatment of skin diseases, the formula is based on the ointment of 1000g of the total amount, and the consumption ratio of various components is as follows:

[0033] Povidone-iodine powder (containing 10% available iodine) 50g

[0034] Itraconazole 15g

[0035] Miconazole Nitrate 15g

[0036] Laurocapram 20g

[0037] Potassium iodate 2g

[0038] Appropriate amount of pH buffer (sodium dihydrogen phosphate / disodium hydrogen phosphate) (adjust pH=6-7)

[0039] Purified water 440g

[0040] Processing aids (glyceryl monostearate 15g, stearic acid 10g, triethanolamine 10g, glycerin 5g, ethylparaben 3g, white petrolatum 60, liquid paraffin 350, aluminum distearate 5g,)

[0041] The total amount of formula is 1000g

[0042] In a 3000ml beaker, put the above-mentioned amount of processing aids and itraconazole (Itraconazole), miconazole nitrate (Miconazole Nitrate), laurocapram (Laurocapram) potassium iodate, heat t...

Embodiment 2

[0046] The povidone-iodine-containing composition for external treatment of skin diseases, the formula is based on a total amount of 1000g ointment, and the dosage ratio of various components is as follows:

[0047] Povidone-iodine powder (containing 10% available iodine) 50g

[0048] Voriconazole 15g

[0049] Econazole 15g

[0050] Laurocapram 20g

[0051] Propylene glycol 10g

[0052] Potassium iodate 2g

[0053] Appropriate amount of pH buffer (sodium dihydrogen phosphate / disodium hydrogen phosphate) (adjust pH=6-7)

[0054] Purified water 638g

[0055] Processing aids (sodium carboxymethylcellulose (CMC) 50g, polyethylene glycol (2000) 100g, glycerin 100g)

[0056] The total amount of formula: 1000g

[0057] Put the additive polyethylene glycol, voriconazole, econazole, laurocapram, propylene glycol and potassium iodate into a 3000ml beaker, heat until the polyethylene glycol melts, and stir the mixture evenly.

[0058] In a mortar, mix 50g of povidone-iodine powder ...

Embodiment 3

[0061] The povidone-iodine-containing composition for external use for the treatment of skin diseases, the formula is based on a total amount of 1000g thickening type liquid, and the dosage ratio of various components is as follows:

[0062] Povidone-iodine powder (containing 10% available iodine) 50g

[0063] Voriconazole 15g

[0064] Miconazole Nitrate 15g

[0065] Laurocapram 20g

[0066] Menthol 10g

[0067] Potassium iodate 2g

[0068] Appropriate amount of pH buffer (sodium dihydrogen phosphate / disodium hydrogen phosphate) (adjust pH=6-7)

[0069] Purified water 768g

[0070] Processing aids (sodium lauryl sulfate 5g, glyceryl monostearate, 5g, sodium carboxymethylcellulose (CMC) 10g, glycerin 100g,)

[0071] Add povidone iodine, potassium iodate, sodium lauryl sulfate, glyceryl monostearate and sodium carboxymethylcellulose into a 3000ml beaker, add purified water, and dissolve completely under stirring;

[0072] Put glycerin, voriconazole, miconazole nitrate, la...

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PUM

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Abstract

The invention discloses an external composition for treating skin diseases. The external composition consists of effective components and pharmaceutically acceptable auxiliary materials. The external composition is characterized in that the effective components of the composition comprise povidone iodine, imidazole and / or triazole antifungal medicines and a skin penetrating agent, wherein a mass ratio of the available iodine content of povidone iodine to the imidazole and / or triazole antifungal medicines to the skin penetrating agent is (3-200):(2-400):(10-1600), and the skin diseases are caused by fungal infection and / or bacterial infection.

Description

technical field [0001] The invention relates to a medicine for treating skin diseases, in particular to an external composition containing povidone-iodine for treating skin diseases. Background technique [0002] At present, the fungal diseases that humans can suffer from can be roughly divided into the following four categories: invasive mycoses and systemic mycoses (such as aspergillosis and candidiasis, etc.), mucosal mycoses (such as "thrush", etc.) , Superficial skin fungal diseases (such as "Hong Kong foot", "onychomycosis", various "dermatophytosis", etc.) and allergic fungal diseases (such as asthma and chronic inflammation, etc.). The first type of fungal disease is very harmful and requires comprehensive treatment with oral antifungal drugs. In addition to oral drug treatment for mucosal mycosis and superficial dermatophytosis, it is more convenient and simple to use external drug treatment. Many skin diseases are often combined bacterial and fungal infections, or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61P17/00A61P31/10A61P31/04A61K31/79
Inventor 郭新秋张冬柏
Owner BEIJING BEIDA MINGDE CHEM PHARMA
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