Bone repair material

Abstract

The invention relates to a bone repair material which is prepared by the following steps: 1, cutting the cancellous bone parts of mammal chines and thighbones into small blocks and then poaching and drying; 2, soaking the cancellous bones by phosphoric acid; 3, putting the cancellous bones in a pressure cooker to cook, rinsing by deionized water and drying; 4, modifying the cancellous bones; and 5, putting the cancellous bones in a high-temperature furnace to calcine. In the bone repair materials, the proportion of hydroxyapatite (HA) to beta-tertiary calcium phosphate (TCP) is between 1: 4 and 4: 1, so that the defects that the HA is too stable and the beta-TCP is degraded too quickly are overcome, the degrading speed of the material can be adjusted through the proportion of the HA to the beta-TCP to ensure that the degrading speed of the material is matched with the growth speed of the surrounding bone tissues and then the function of remarkably promoting bone healing is provided; and the bone repair material has certain hardness and strength, is easy to plasticize and rich in source, and can be used for solving the manufacturing difficulties of artificial synthetic materials in the aspects of porosity, pore traffic and pore size.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and relates to a bone repair material, which is used for bone filling and repair of human bone defects. Background technique [0002] my country is entering an aging society, and age-related changes and accompanying diseases will lead to a large number of bone defect reconstruction needs. Traditional bone graft scaffold materials include xenograft bone, allograft bone, synthetic materials, etc. All of the above materials have certain limitations. Limitations: Allogeneic bone sources are limited; xenogeneic bone has source and price issues, and there are risks of spreading diseases and causing host immune rejection; the porosity, pore traffic, and pore size of synthetic materials are different from those of human cancellous bone. Different, it is unfavorable to the adhesion and proliferation of cells, and it is difficult to promote the differentiation and maturation of osteoblasts. [0003] Hydr...

AI Technical Summary

Problems solved by technology

[0002] my country is entering an aging society, and age-related changes and accompanying diseases will lead to a large number of bone defect reconstruction needs. Traditional bone graft scaffold materials include xenograft bone, allograft bone, synthetic materials, etc. All of the above materials have certain limitations. Limitations: Allogeneic bone sources are limited; xenogeneic bone has source and price issues, and there are risks of spreading diseases and causing host immune rejection; the porosity, pore traffic, and pore size of synthetic materials are different from those of human cancellous bone. Different, it is unfavorable to the adhesion and proliferation of cells, and it is difficult to promote the differentiation and maturation of osteoblasts

β-tricalcium phosphate (β-TCP) not only has good biocompatibility, but also has good biodegradability, and its degradation product Ca 2+ 、PO 4 3- Plasma can enter the body fluid of the living body to provide abundant Ca, P and other beneficial elements for the formation of new bone, and promote the formation of new bone, but the degradation rate of β-TCP in the body is slightly faster, which does not match the growth rate of new bone

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