Method for preparing alveolar bone repair material

Abstract

The invention relates to a method for preparing an alveolar bone repair material. The method comprises the following steps: step 1, cutting cancellous bone parts of chine and thigh bone of a mammal into pieces, poaching and drying; step 2, soaking the cancellous bone by using phosphoric acid; step 3, cooking the cancellous bone in a pressure cooker, bleaching by using deionized water, and drying; step 4, modifying the cancellous bone; step 5, calcining the cancellous bone in a high temperature stove; and step 6, crushing and screening the calcined cancellous bone. According to the alveolar bone repair material prepared by utilizing the method, the ratio of hydroxyapatite (HA) to beta-tertiary calcium phosphate (beta-TCP) in the components is between 1:4 and 4:1, the defects that the HA is extremely stable and beta-TCP is extremely quickly degraded are overcome, and the degradation speed of the material can be adjusted by virtue of the ratio between HA and beta-TCP, so that the degradation speed is matched with the growth speed of surrounding bone tissues, and the material has an obvious effect of promoting bone healing. Moreover, the material has a certain hardness and strength and is simple in plasticity and rich in source, and the manufacture problems of artificial synthetic materials in aspects such as porosity, pore traffic and pore size are solved.

Description

technical field [0001] The invention belongs to the field of preparation of medical biological materials, and relates to a preparation method of an alveolar bone repair material, which is used for alveolar bone filling and repair. Background technique [0002] my country is entering an aging society, and age-related changes and accompanying diseases will lead to a large number of bone defect reconstruction needs. Among them, bone defects caused by tooth loss are common in the oral cavity of Chinese people, and patients with tooth loss are often accompanied by varying degrees. The alveolar bone defect of the patient needs to be repaired and reconstructed with bone filling material. Traditional bone graft scaffold materials include xenograft bone, allograft bone, synthetic materials, etc. All of the above materials have certain limitations: the source of allograft bone is limited; xenograft bone has source and price problems, and at the same time, it may spread diseases and cau...

AI Technical Summary

Problems solved by technology

Traditional bone graft scaffold materials include xenograft bone, allograft bone, synthetic materials, etc. All of the above materials have certain limitations: the source of allograft bone is limited; xenograft bone has source and price problems, and at the same time, it may spread diseases and cause host Risks such as immune rejection; the porosity, pore traffic, and pore size of synthetic materials are different from those of human cancellous bone, which is not conducive to cell adhesion and proliferation, and it is difficult to promote the differentiation and maturation of osteoblasts

β-tricalcium phosphate (β-TCP) not only has good biocompatibility, but also has good biodegradability, and its degradation product Ca 2+ 、PO 4 3- Plasma can enter the body fluid of the living body to provide abundant Ca, P and other beneficial elements for the formation of new bone, and promote the formation of new bone, but the degradation rate of β-TCP in the body is slightly faster, which does not match the growth rate of new bone

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