Gluconic acid chlorhexidine composite gargle and preparation method thereof
A technology of chlorhexidine gluconate and gluconate sugar acid, which is applied in the field of medicine, can solve the problems of precipitation in the storage process and unstable product quality, achieve enhanced curative effect, reduce the production of harmful substances p-chloroaniline, and improve stability Effect
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experiment example 1
[0021] Experimental example 1: the selection of polysorbate 80, polyethylene glycol 400 dosage
[0022] 1. Purpose of the experiment
[0023] To investigate the effect of the dosage of polysorbate 80 and polyethylene glycol 400 on the quality of chlorhexidine gluconate compound gargle of the present invention.
[0024] 2. Equipment: dissolving tank (barrel), stirrer, several 1000ml beakers, several 1000ml volumetric flasks, several weighing instruments, several pipettes, one 1000ml measuring cylinder, several 200ml compound gargle bottles.
[0025] 3. Materials: configure the corresponding required raw and auxiliary materials for the chlorhexidine gluconate compound gargle of the present invention. As in Table 1.
[0026] Table 1: configure the corresponding raw and auxiliary materials required for the chlorhexidine gluconate compound gargle of the present invention
[0027]
[0028] 4. Operation steps:
[0029] 4.1 Dosage of polysorbate 80:
[0030] 4.1.1 Prepare the...
experiment example 2
[0055] Experimental Example 2: The way of adding lemon yellow pigment
[0056] 1. Purpose of the experiment
[0057] To explore the effect of the way of adding tartrazine on the product quality of chlorhexidine gluconate compound gargle of the present invention.
[0058] 2. Equipment: Same as Experiment 1.
[0059] 3. Materials: Same as experimental example 1.
[0060] 4. Operation steps:
[0061]4.1 Prepare 4 parts of 5000ml intermediate solution according to the process prescription in Table 2 without adding lemon yellow pigment as follows:
[0062] 4.1.1 Take 5.5g of polysorbate 80 and 1g of metronidazole raw powder and add them to container A and stir at a stirring speed of 60 rpm. After stirring for 20 minutes, continue stirring and take 223g of ethanol and add in five times , 45g each time for the first four times, 43g for the fifth time, then add 1.85g banana essence, 50g mint water and stir for 20 minutes at a stirring speed of 60 rpm to obtain feed liquid A;
[...
experiment example 3
[0079] Experimental example 3: sodium saccharin, peppermint water concentration affect the mouthfeel of chlorhexidine gluconate compound gargle of the present invention
[0080] 1. Purpose of the experiment
[0081] 1) Discuss the effect of sodium saccharin and peppermint water concentration on the mouthfeel of the chlorhexidine gluconate compound gargle of the present invention, and seek the best mouthfeel sodium saccharin and peppermint water formula.
[0082] 2) Discuss the influence of saccharin sodium and peppermint water concentration on the quality of chlorhexidine gluconate compound gargle of the present invention.
[0083] 2. Equipment: Same as Experiment 1.
[0084] 3. Materials: Same as experimental example 1.
[0085] 4. Operation steps:
[0086] 4.1 Experiment with only changing the dosage of sodium saccharin:
[0087] 4.1.1 Prepare the intermediate solution for the experiment: According to the process prescription in Table 2, prepare 5000ml of the intermediat...
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