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Disposable intranasal brain targeted drug delivery device

A drug delivery device and brain-targeting technology, which is applied in the direction of drug devices, other medical devices, and nebulizers for treatment, can solve the problems of inability to deliver drugs to the olfactory area of ​​the nasal cavity, waste of drugs, and inability to use them. The effect of avoiding repeated cleaning and reducing potential hidden dangers

Active Publication Date: 2015-06-03
TONGLI BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the nasal cavity olfactory area drug delivery device in the prior art also has the following disadvantages: 1) Although the nozzle of the drug delivery device can deliver the drug to the nasal cavity olfactory area, the nozzle cannot extend into the nasal cavity olfactory area, so the drug cannot be completely injected into the nasal cavity. Sent to the nasal olfactory area, as in the prior art, only about 64% of the drug can be sent to the nasal olfactory area, resulting in waste of drugs and unnecessary economic losses to patients
2) The drug delivery device is not a pre-packaged design, and it needs to be reloaded and dispensed every time the drug is administered. It is possible that due to the waste of filling and dispensing time, patients cannot be treated in time
3) Because the drug needs to be re-prepared and administered every time the drug is administered, the drug storage container needs to be opened frequently, which can easily cause the drug to deteriorate and cannot be used, especially for some drugs with low storage stability, it is easy to cause waste
4) The cumbersome steps of cleaning and disinfection are required for each drug administration. If the cleaning and disinfection are not thorough, it is easy to cause cross-contamination

Method used

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  • Disposable intranasal brain targeted drug delivery device
  • Disposable intranasal brain targeted drug delivery device
  • Disposable intranasal brain targeted drug delivery device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] like figure 1 As shown, a disposable nasal-brain targeted drug delivery device includes a drug delivery device, and the drug delivery device includes a container with an inner cavity for storing preparations. The container can be deformed under the action of an external force so that the A squeezable container 1 in which the pressure in the container changes, and the applicator also includes a conduit 2 communicating with the squeezable container 1 for introducing the preparation in the squeezable container 1 into the nasal cavity and a spray tube arranged at one end of the conduit 2 Head 4, one end of the conduit 2 provided with the spray nozzle 4 can extend through the common nasal passage of the human body into the nasal cavity olfactory area above the level corresponding to the middle turbinate, and the other end of the conduit 2 is connected to the extrudable container 1. The dispenser also includes a pressure-sensitive membrane 3 for isolating the lumen of the squ...

Embodiment 3

[0072] like image 3 As shown, a disposable nasal-brain targeted drug delivery device includes a container with an inner cavity for storing preparation components. The drug delivery device in this example is similar to that in Example 2, except that the container used is different, and the container used in this example is a syringe 10 .

[0073] The pressure sensitive membrane 3 is arranged in the lumen of the syringe 10 , and the soluble membrane 9 is arranged at the connection between the catheter 2 and the syringe 10 .

[0074] How the drug delivery device works in this example:

[0075] Both the first chamber 7 and the second chamber 8 are stored with preparation components, and the solvent that can dissolve the soluble film 9 is stored in the first chamber 7. Extend through the common nasal passage of the human body to the nasal olfactory area above the level corresponding to the middle turbinate, and then push the piston 101 of the syringe 10 to squeeze the preparatio...

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Abstract

The invention relates to a disposable intranasal brain targeted drug delivery device. The disposable intranasal brain targeted drug delivery device comprises a drug deliverer, wherein the drug deliverer comprises a container which is provided with an inner cavity and is used for storing a preparation, a guide pipe which is communicated with the container and is used for guiding the preparation in the container into a nasal cavity, and an atomizing spray head arranged at one end of the guide pipe; one end, provided with the atomizing spray head, of the guide pipe can stretch into a nasal cavity smelling region above the horizontal position corresponding to a concha nasalis media of the meatus nasi communis of a human body to efficiently transmit the preparation into the nasal cavity smelling region, and then the preparation is directly adsorbed into a brain to express the treatment effect in a central nervous system.

Description

technical field [0001] The invention relates to a disposable nasal-brain targeted drug delivery device. Background technique [0002] In the treatment of brain diseases such as multiple sclerosis, Parkinson's disease, epilepsy, Alzheimer's disease, brain tumors, AIDS and other infectious diseases and acute poisoning, there has always been a difficult problem in medicine, namely: how to Overcoming the blood-brain barrier allows drugs to quickly enter the central nervous system (central nervous system, CNS) to exert their medicinal effects. At present, the most clinically used method is to reversibly open the blood-brain barrier, intrathecal injection and carotid artery injection, so that the drug can penetrate and enter the central nervous system. However, these methods require high technical requirements and high safety risks, and are subject to certain restrictions in application. Based on the special structure of the nasal cavity, the treatment of brain diseases through ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M11/00A61M31/00
Inventor 钱明心何仁扬施俊巍
Owner TONGLI BIOMEDICAL
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