Compositions and methods for treating and inhibiting viral infections

Abstract

Compositions and methods for the treatment, as well as the inhibition and prevention, of an infection of the papillomavirus and the epithelial lesions, namely, the waits of the skin and mucosal surfaces, associated therewith, in a mammalian host, as well as methods of inhibiting the replication of a papillomavirus in an infected cell, are provided. The compositions comprise a therapeutically effective amount of an active ingredient comprising at least one compound selected from the group consisting of chloroquine, hydroxychloroquine, amodiaquine, or in each case, a pharmaceutically acceptable salt thereof. The methods comprise topically administering a therapeutically and/or antivirally effective amount of such a compound to a mammalian host, such as a human being, in need of such treatment, although alternatively other routes of administration may be used, including but not limited to transdermal, transmucosal, respiratory, and by injection. The compositions optionally also comprise one or more pharmaceutically acceptable non-active ingredients.

Description

technical field [0001] The present invention relates generally to methods for treating and inhibiting papillomavirus infection and removing warts of papillomavirus origin (genesis) in mammalian hosts, and in particular, to the treatment and prevention of warts associated with papillomavirus infection in mammals. Compositions and methods for genital warts and other warts and lesions of skin and mucous membrane surfaces. More specifically, the present invention relates to compositions and methods for treating and inhibiting the replication of human papillomaviruses, thereby eliminating the cause of these warts and lesions. Background technique [0002] Human papillomavirus is a virus of the papillomaviridae family that infects the epidermis of humans. This infection can lead to epithelial damage or growth, especially warts, also known as genital warts or papillomas. A number of different HPV types have been identified, which are usually transmitted by skin-to-skin contact (or...

AI Technical Summary

Problems solved by technology

Others use drugs that adjust the immune response to the virus in order to treat the warts, but these usually take more time to fight the virus and end the warts, which don't always appear

Also, while these methods can be used to target and treat existing warts, they do not necessarily treat the underlying virus, which can cause the wart to regrow, since warts are a manifestation of a viral infection

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