Traditional Chinese medicine extract with antitumor effect as well as extraction method and application thereof

A technology of anti-tumor drugs and extraction methods, which is applied in the field of traditional Chinese medicine extracts with anti-tumor effects, can solve the problems of cancer prevention and treatment medical workers, and the combination of anti-cancer and anti-cancer drugs has not been found. , to achieve good anti-tumor effect, suitable for large-scale industrial production, and high scientific research value

Inactive Publication Date: 2015-06-17
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Innovative drug research and development is a major research field in the national science and technology plan. Although there are many research reports on basic anti-cancer and anti-cancer drugs, there are no reports on specific drugs that can be used in actual clinical use. It is a huge problem for medical workers, so the study of new anti-cancer and anti-cancer drugs is still the focus of medical research workers, and it has not been found before that there is no joint application of S. cotta and Nuxychia as anti-cancer and anti-cancer drugs. Related reports

Method used

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  • Traditional Chinese medicine extract with antitumor effect as well as extraction method and application thereof
  • Traditional Chinese medicine extract with antitumor effect as well as extraction method and application thereof
  • Traditional Chinese medicine extract with antitumor effect as well as extraction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1) Extraction of mussel seeds

[0036] According to mass parts, crush 6 parts of Momordica chinensis medicinal materials to obtain Momordica chinensis minced, adopt Soxhlet extraction method, add n-hexane, soak the Momordica chinensis minced for 12h, and then heat and reflux at 68℃ for 6h. Extract, discard the obtained extract, then add ethyl acetate to the extracted cochinchinensis powder, heat reflux for 6h at 76°C for extraction, collect the obtained extract, and then recover the solvent in the extract under reduced pressure , After concentrating, obtain the cochinchinensis extract; the volume of the added n-hexane is 6 times the volume of the cochinchinensis powder, and the volume of ethyl acetate is 6 times the volume of the cochinchinensis powder;

[0037] 2) Extraction of horse money seeds

[0038] Crush 4 parts of Strychoma serrata medicinal materials, and extract with pH=5 and 50% volume fraction of ethanol by heating and refluxing. The volume of ethanol is 6 times t...

Embodiment 2

[0041] 1) Extraction of mussel seeds

[0042] In terms of parts by mass, crush 3 parts of Momordica chinensis medicinal material to obtain Momordica chinensis squash. Soxhlet extraction method is used, and n-hexane is added to soak the saccharine squash for 20h, and then heat and reflux for 5h at 66℃. Extraction, discard the obtained extract, then add ethyl acetate to the extracted cochinchinensis seeds, heat and reflux at 72℃ for 7h for extraction, extract twice, collect the obtained extract, and then recover and extract under reduced pressure The solvent in the liquid is concentrated to obtain the Motobill extract; the volume of n-hexane added is 8 times the volume of Motobill, and the volume of ethyl acetate is 7 times the volume of Motobill;

[0043] 2) Extraction of horse money seeds

[0044] Crushed 8 parts of Strychoma serrata medicinal materials, and extracted with pH=4 and 40% volume fraction of ethanol by heating and refluxing. The volume of ethanol is 7 times the volume o...

Embodiment 3

[0047] 1) Extraction of mussel seeds

[0048] According to the mass parts, 9 parts of Momordica sinensis medicinal materials are crushed to obtain Momordica sinensis fragments. Soxhlet extraction method is used, and n-hexane is added. The Momordica sinensis fragments are soaked for 16h, and then heated to reflux for 8h at 70℃. Extract, discard the obtained extract, then add ethyl acetate to the extracted cochinchinensis seeds, heat reflux for 5h at 80℃ for extraction, extract three times, collect the obtained extract, and then recover the extract under reduced pressure After concentrating the solvent in, the Motobill extract is obtained; the volume of n-hexane added is 7 times the volume of Motobill, and the volume of ethyl acetate is 8 times the volume of Motobill;

[0049] 2) Extraction of horse money seeds

[0050] Crush 2 parts of Strychoma serrata medicinal material, and extract with pH=6 and 45% volume fraction of ethanol by heating and refluxing. The volume of ethanol is 8 ti...

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Abstract

The invention provides a traditional Chinese medicine extract with an antitumor effect as well as an extraction method and application thereof. In parts by mass, the traditional Chinese medicine extract comprises 3-9 parts of semen momordicae and 2-8 parts of semen strychni. The extraction method comprises the following steps: respectively extracting a semen momordicae extract and a semen strychni extract; and mixing the two extracts to obtain the traditional Chinese medicine extract, wherein the semen momordicae extract is obtained by extracting the semen momordicae by normal hexane, discarding the extracting solution and extracting the obtained extract by ethyl acetate, and the semen strychni extract is obtained by extracting the semen strychni by ethyl alcohol. The traditional Chinese medicine extract can be applied to the preparation of antitumor drugs, and can be used as a medicinal component to be prepared into capsules or tablets by adding auxiliary materials. By combining the semen momordicae and the semen strychni, the traditional Chinese medicine extract has a favorable antitumor effect; and through the medicine synergism of the semen momordicae and the semen strychni, the antitumor effect can be maximized; therefore, the traditional Chinese medicine extract has a high scientific research value and a favorable application prospect.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine extract with anti-tumor effect and an extraction method and application thereof. Background technique [0002] Tumors have become a major problem that seriously threatens human health, and their morbidity and mortality have been increasing year by year. According to the World Health Organization (WHO) report, it is estimated that between 2007 and 2030, the number of new cancer cases worldwide will increase from 11.3 million to 15.5 million, and the number of cancer deaths will increase from 7.9 million to 11.5 million, an increase of up to 45%, so prevention and control face greater challenges. Finding drugs from plants has become an important source of anti-tumor drug research worldwide. Current studies have shown that many natural plant extracts have good anti-tumor activity, and many natural products or their structural modification comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/56A61P35/00
Inventor 张彦民郑蕾展颖转张东东马维娜贺浪冲祁军鹏欧阳小艳
Owner XI AN JIAOTONG UNIV
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