Novel function of active ingredients of cortex dictamni for promoting increment expression of dopamine transporter

A technology of active ingredients, white fresh skin, applied in the directions of medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, plant raw materials, etc.

Active Publication Date: 2015-07-01
山东中科绿碳科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Novel function of active ingredients of cortex dictamni for promoting increment expression of dopamine transporter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The separation process of the active ingredient of white fresh skin is:

[0018] Use 95% ethanol and 10 times of 70% ethanol to recover and extract 5 kg of white fresh cortex successively for three times, each time for one hour, combine the extracts, concentrate to obtain extract and suspend with water, then use petroleum ether, two Methylene chloride and ethyl acetate were extracted to obtain about 50 g of dichloromethane extracts, which were the active ingredients of the Cortex Dictatus.

Embodiment 2

[0020] 10kg of white fresh cortex was sequentially recovered and extracted three times with 95% ethanol and 10 times of 70% ethanol, each time for one hour, the extracts were combined, concentrated to obtain extracts and suspended with water, then sequentially used petroleum ether, dichloro Extract with methane and ethyl acetate to obtain about 100 g of dichloromethane extract, which is the active ingredient of the Cortex Dictatus.

Embodiment 3

[0022] Use 95% ethanol and 10 times of 70% ethanol to recover and extract 8 kg of white fresh cortex successively for three times, each time for one hour, combine the extracts, concentrate to obtain extract and suspend with water, then use petroleum ether, two Methylene chloride and ethyl acetate were used for extraction to obtain about 80 g of dichloromethane extracts, which were the active ingredients of the Cortex Dictatus.

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Abstract

Cortex dictamni is an important traditional Chinese medicinal material. The invention introduces a novel function of active ingredients of cortex dictamni. The action experiment of the active ingredients of cortex dictamni for primary neuron of rats discovers that overexpression of a dopamine transporter gene DAT can be promoted by adding the active ingredients of cortex dictamni, dopaminergic neuron has an important influence on motion, addiction, motion control and other behaviors, and results indicate that changes of human body pleasant sensation, motion control and other functions can be promoted by means of application of the active ingredients of cortex dictamni.

Description

technical field [0001] The present application belongs to the technical field of new functions of active ingredients of medicinal materials, and in particular relates to a new function that an active ingredient isolated from the traditional Chinese medicinal material Cortex Pleurotus can promote the increased expression of dopamine transporter in hippocampal neurons. Background technique [0002] Dopamine is an important neurotransmitter located in the central nervous system of humans and mammals. Dopamine is abundantly expressed in the hypothalamus, hippocampus and other brain regions, and their effects can directly affect people's emotions and cause pleasure. At the same time, dopaminergic neurons are also widely recognized as the main organismal bearers of the phenomenon of addiction. During the action of dopaminergic neurons, dopamine transporter (Dopamine transporter, DAT) and dopamine receptor (Dopamine receptor, DA) are mainly involved in the core neurotransmission...

Claims

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Application Information

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IPC IPC(8): A61K36/75A61P25/00
Inventor 不公告发明人
Owner 山东中科绿碳科技有限公司
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