Agentia for preventing toxoplasma infection and application

A technology for infection prevention and toxoplasma, which is applied in the field of immune vaccines to achieve the effect of enhancing the immune effect

Active Publication Date: 2015-07-29
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complexity of the life cycle of Toxoplasma gondii and its infection, there are no safe and effective drugs and vaccines against Toxoplasma gondii infection. significance

Method used

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  • Agentia for preventing toxoplasma infection and application
  • Agentia for preventing toxoplasma infection and application
  • Agentia for preventing toxoplasma infection and application

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A medicament for preventing Toxoplasma gondii infection of the present invention, which is prepared by adsorbing TLR7 / 8 agonist CL097 with aluminum hydroxide adjuvant (Imject Alum), and the adsorption step is: 40 μl of PBS with pH7.4 at room temperature Incubate with 50 μl Imject Alum for 30 min, then add 10 μl of 5 μg CL097, and absorb on ice for 30 min to complete the preparation of the immune adjuvant. In use, it is injected into the leg muscles of mice. The content of aluminum hydroxide adjuvant (Imject Alum) is 40mg / ml aluminum hydroxide and 40mg / ml magnesium hydroxide.

Embodiment 2

[0026] A medicament for preventing Toxoplasma gondii infection of the present invention, which is prepared by adsorbing TLR7 / 8 agonist CL097 with an aluminum hydroxide adjuvant (Imject Alum), and the adsorption step is: 50 μl of PBS with a pH of 7.4 at room temperature Incubate with 45 μl Imject Alum for 30 min, then add 10 μl of 5 μg CL097, and absorb on ice for 30 min to complete the preparation of the immune adjuvant. In use, it is injected into the leg muscles of mice. The content of aluminum hydroxide adjuvant (Imject Alum) is 40mg / ml aluminum hydroxide and 40mg / ml magnesium hydroxide.

Embodiment 3

[0028] A medicament for preventing Toxoplasma gondii infection of the present invention, which is prepared by adsorbing TLR7 / 8 agonist CL097 with aluminum hydroxide adjuvant (Imject Alum), and the adsorption step is: 60 μl of PBS with pH7.4 at room temperature Incubate with 50 μl Imject Alum for 30 min, then add 10 μl of 5 μg CL097, and absorb on ice for 30 min to complete the preparation of the immune adjuvant. In use, it is injected into the leg muscles of mice. The content of aluminum hydroxide adjuvant (Imject Alum) is 40mg / ml aluminum hydroxide and 40mg / ml magnesium hydroxide.

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Abstract

The invention provides agentia for preventing toxoplasma infection. The agentia is prepared in a way that aluminium hydroxide adjuvant adsorbs TLR7 / 8 agonist CL 097. The agentia, as immunologic adjuvant, can enhance the immune effect of toxoplasma vaccine and can also serve as toxoplasma vaccine independently.

Description

technical field [0001] The invention belongs to the technical field of immune vaccines, in particular to a medicament for preventing toxoplasma gondii infection. Background technique [0002] Toxoplasmosis is a ubiquitous zoonotic intracellular parasitic disease caused by Toxoplasma gondii infection. Economic losses. Humans can become infected if they eat undercooked food or come into contact with oocysts in the environment. At present, about 1 / 3 of the world's people suffer from toxoplasmosis. Most adults with normal immunity do not have obvious symptoms, but those with low or impaired immune function (such as pregnant women, organ transplant recipients, HIV patients, etc.) often develop severe toxoplasmosis. even fatal injuries. However, due to the complexity of the life cycle of Toxoplasma gondii and its infection, there are no safe and effective drugs and vaccines against Toxoplasma gondii infection. significance. Contents of the invention [0003] The invention p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61K39/002A61P33/02
Inventor 朱兴全胡玲英周东辉徐民俊黄思扬
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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