Lipopeptide molecule surfactant containing azobenzene photosensitive group, and synthetic method thereof

Abstract

The invention relates to a chemical synthetic method of a lipopeptide molecule, and especially relates to a lipopeptide molecule surfactant containing an azobenzene photosensitive group, and a synthetic method thereof. The lipopeptide with small molecular weight is synthesized through a liquid phase synthesis process, contains a small number of amino acids and can be easily synthesized through few reaction steps, and the synthesis efficiency and the purity of the lipopeptide with small molecular weight are high; the yield of every step in a synthesis route is high, and a separation and purification process is simple, so the consumption of a raw material and the waste of a product are reduced; and the azobenzene photosensitive group is effectively embedded into a fatty acid chain through the liquid phase synthesis process in order to bind a specific function group.

Description

technical field [0001] The invention relates to a chemical synthesis method of lipopeptide molecules, in particular to a lipopeptide molecule surfactant containing an azobenzene photosensitive group and a synthesis method thereof. Background technique [0002] Polypeptide molecules are compounds between proteins and amino acids, and are important active substances involved in life activities in organisms. They have the advantages of no toxic side effects, good biocompatibility, and degradability. [0003] Lipopeptide is a special type of polypeptide molecular derivative, which has surface and interface properties similar to surfactants, and has the advantages of biocompatibility and biological activity of polypeptide molecules. It is widely used in materials science, tissue engineering, nanoscience, and biomedicine. And other fields have shown broad application prospects, and become research hotspots in these fields. [0004] In addition to the synthesis of natural lipopept...

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Problems solved by technology

[0005] 1. Usually the conversion rate is low, and the reaction raw materials in each step need to be excessive, resulting in high product cost and very expensive product price;

[0006] 2. The synthesis efficiency is low, and large-scale synthesis cannot be realized, and it is difficult to meet the requirements of products with large demand;

[0007] 3. There are certain difficulties in the one-step synthesis of lipopeptide molecules with special modifications, which require special treatment before synthesis, and some cannot even be achieved by solid-phase synthesis

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