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Drug application of lariciresinol-4-O-beta-D-glucoside and pharmaceutical composition thereof

A kind of technology of larchiferin and glucoside

Active Publication Date: 2015-08-19
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is no relevant literature report on the application of agaricin-4-O-β-D-glucoside in the treatment of influenza.

Method used

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  • Drug application of lariciresinol-4-O-beta-D-glucoside and pharmaceutical composition thereof
  • Drug application of lariciresinol-4-O-beta-D-glucoside and pharmaceutical composition thereof
  • Drug application of lariciresinol-4-O-beta-D-glucoside and pharmaceutical composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]Example 1 Separation, purification and structural identification of larchoresin-4-O-β-D-glucoside

[0028] According to the existing extraction and separation methods in this field, extract and separate from the Radix Radix Radix Radix methanol extract to obtain larchoresin-4-O-β-D-glucoside, specifically, suspend 500g of Radix Radix Radix Radix methanol extract with water, and then use ethyl acetate, Extraction with n-butanol, 70 g of n-butanol is further desugared by macroporous resin HPD100, and 95% ethanol is collected to recover the solvent to obtain about 45 g of extract. The extract was subjected to silica gel column chromatography (200-300 mesh, 5×30cm), eluted with chloroform-methanol gradient (100:0-98:2-95:5-9:1-2:1-0:1, v / v) 13 components Fr.1-Fr.13 are obtained. Fr.11 was purified by preparative MPLC and eluted with methanol-water gradient (0:100-100:0, v / v) to obtain 7 components A-G. Fr.C was further purified by silica gel column chromatography to obtain ...

Embodiment 2

[0031] Example 2 Preparation of larchoresin-4-O-β-D-glucoside tablet

[0032] Weigh each component according to the following formula:

[0033]

[0034] Tablets were prepared according to the conventional preparation method of tablets in the field of pharmacy, and 1000 tablets were made in total, each containing 5 mg of agaricin-4-O-β-D-glucoside. The usage of this tablet is: 2-4 tablets each time, 3 times a day, seven days as a course of treatment.

Embodiment 3

[0035] Example 3 Preparation of larchoresin-4-O-β-D-glucoside capsules

[0036] Weigh each component according to the following formula:

[0037]

[0038] Prepared according to the conventional method of capsules in the field of pharmacy, a total of 1000 capsules were made, and each capsule contained 5 mg of agaricin-4-O-β-D-glucoside. Usage of the capsule: 2-4 capsules each time, 3 times a day, seven days as a course of treatment.

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PUM

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Abstract

The invention relates to an application of lariciresinol-4-O-beta-D-glucoside in the preparation of drugs for treating or preventing flu and related inflammatory diseases caused by influenza virus. The application of lariciresinol-4-O-beta-D-glucoside in clinical treatment of influenza virus diseases has characteristics of safety, effectivity and little toxic or side effect. The invention also provides a pharmaceutical composition, an active ingredient of which comprises lariciresinol-4-O-beta-D-glucoside. By cytopathic-effect inhibition assay, it is verified that lariciresinol-4-O-beta-D-glucoside has an effect of inhibiting replication of influenza virus in the treatment mode. The result proves that lariciresinol-4-O-beta-D-glucoside has obvious effect of inhibiting influenza virus in the treatment mode. Selection index SI is greater than 4. The lariciresinol-4-O-beta-D-glucoside has advantages of low toxicity and high effectiveness.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the application of larchoresin-4-O-β-D-glucoside in treating or preventing influenza and inflammatory diseases caused by influenza virus. The invention also relates to a pharmaceutical composition containing the composition for resisting influenza virus and treating inflammatory diseases caused by influenza virus. Background technique [0002] Influenza (abbreviated as flu) is an acute respiratory infection caused by influenza virus, which can be transmitted through the air. Although seasonal influenza is self-limiting, because influenza virus can cause secondary bacterial infection, the infected person will develop pneumonia and severe lung damage, resulting in high morbidity and mortality. According to statistics, the annual influenza season Between 250,000 and 500,000 people died of influenza worldwide. Existing anti-influenza drugs M2 ion channel inhibitors (amantadine drugs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P31/16A61P29/00
Inventor 杨子峰姜志宏李菁周倍贤王玉涛李征途陈荣昌钟南山
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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