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A kind of cellulose-based dressing and its preparation method and application

A cellulose-based, cellulose-based technology, applied in the field of functional polymer materials, can solve the problems of uneven coating of surface functional substances, complicated processes, etc., and achieves accelerated epithelial cell growth, good repeatability, and simple and easy preparation methods. Effect

Inactive Publication Date: 2017-10-10
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these preparation methods also have some problems. For example, some substrates do not have a natural pore structure, and a porogen needs to be added to prepare the pore structure. The porogen may need to be removed in the later stage, and the process is relatively complicated; The selection of functional substances has certain limitations; the membrane impregnation method may cause uneven coating of surface functional substances inside the membrane, etc.

Method used

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  • A kind of cellulose-based dressing and its preparation method and application
  • A kind of cellulose-based dressing and its preparation method and application
  • A kind of cellulose-based dressing and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A preparation method of cellulose-based dressing, the specific steps are as follows:

[0041] 1) Pre-cool NaOH / urea aqueous solution (the mass ratio of sodium hydroxide, urea, and water is 7:12:81) to -12°C as a cellulose solvent to dissolve cellulose and perform defoaming and impurity removal to obtain cellulose quality 4% cellulose solution;

[0042] 2) Pour the cellulose solution prepared in step 1) on one end of the glass plate, prepare a sulfuric acid solution with a mass concentration of 5% as a solidification solution, and use a casting method to solidify the cellulose solution in the solidification solution to a thickness of 0.25 mm. Porous cellulose membrane;

[0043]3) preparation mass concentration is the chitosan solution (surface modification solution) of 3%, the porous cellulose membrane that step 2) is made is as the osmotic membrane in the pressurized osmotic device, adopts ultrafiltration to make 2ml chitosan solution Through the holes of the cellulos...

Embodiment 2

[0046] A preparation method of cellulose-based dressing, the specific steps are as follows:

[0047] 1) Pre-cool NaOH / urea aqueous solution (the mass ratio of sodium hydroxide, urea, and water is 7:12:81) to -12°C as a cellulose solvent to dissolve cellulose and perform defoaming and impurity removal to obtain cellulose quality 4% cellulose solution;

[0048] 2) Pour the cellulose solution prepared in step 1) on one end of the glass plate, prepare a sulfuric acid solution with a mass concentration of 5% as a solidification solution, and use a casting method to solidify the cellulose solution in the solidification solution to a thickness of 0.25 mm. Porous cellulose membrane;

[0049] 3) preparation mass concentration is the chitosan solution (surface modification solution) of 1%, the porous cellulose membrane that step 2) is made is as the osmotic membrane in the pressurized osmotic device, adopts suction filtration method to make 10ml chitosan solution Through the holes of ...

Embodiment 3

[0052] A preparation method of cellulose-based dressing, the specific steps are as follows:

[0053] 1) Pre-cool NaOH / urea aqueous solution (the mass ratio of sodium hydroxide, urea, and water is 7:12:81) to -12°C as a cellulose solvent to dissolve cellulose and perform defoaming and impurity removal to obtain cellulose quality 4% cellulose solution;

[0054] 2) Pour the cellulose solution prepared in step 1) on one end of the glass plate, prepare a sulfuric acid solution with a mass concentration of 5% as a solidification solution, and use a casting method to solidify the cellulose solution in the solidification solution to a thickness of 0.25 mm. Porous cellulose membrane;

[0055] 3) preparation mass concentration is the chitosan solution (surface modification solution) of 3%, the porous membrane that step 2) is made is used as the osmotic membrane in pressurized osmotic device, adopts ultrafiltration method to make 10ml chitosan solution through fiber The pores of the pl...

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Abstract

The invention discloses a cellulose-based dressing, the preparation method of which comprises the following steps: 1) pre-cooling the cellulose solvent to -12--5°C, then adding cellulose, stirring and dissolving, performing defoaming and impurity removal to obtain Cellulose solution; 2) The cellulose solution is poured on one end of the glass plate, and it is solidified in the solidification liquid by casting method to form a porous cellulose membrane; 3) The cellulose membrane prepared in step 2) is used as a pressurized The permeation membrane in the permeator is prepared, and the surface modification solution is prepared to dynamically permeate the cellulose membrane through the pores of the cellulose membrane, and finally washed with water and dried to obtain the cellulose-based dressing. The preparation method involved in the present invention is simple, low in cost, green and non-toxic, and has good repeatability; the prepared cellulose-based dressing not only has a uniform pore structure, excellent strength and toughness, but also has high transparency and the ability to absorb exudates ; and has good hemostatic effect, can significantly promote wound healing, and is safe to use, and is expected to be popularized and used clinically.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials, and in particular relates to a cellulose-based dressing and its preparation method and application. Background technique [0002] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. With the aging population and the increase of chronic ulcerative wounds, the market value of medical dressings is also becoming more and more important. In the second half of the 19th century, the surgeon Gamgee invented the absorbent and antibacterial Gamgee dressing, a cotton pad. Since Dr. George Winter, a British scientist, discovered that a humid environment is beneficial to wound healing in 1962, and put forward the "moist wound healing theory", people have made breakthroughs in understanding the wound healing process, and various new ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/26A61L15/42A61L15/44
Inventor 喻发全曹珍妮罗晓刚张浩薛亚楠蔡宁
Owner WUHAN INSTITUTE OF TECHNOLOGY