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A preparation method of cellulose and chitosan composite dressing containing mesoporous silica

A technology of mesoporous silica and cellulose, applied in the fields of medical science, absorbent pads, bandages, etc., can solve problems such as poor mechanical properties, and achieve the effects of good moisture retention, fast film forming speed, and resistance to bacterial invasion.

Active Publication Date: 2021-11-02
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The existing chitosan-containing dressings have poor mechanical properties, because the cellulose selected in this process has excellent mechanical properties. On this basis, chitosan is compounded, which not only retains the natural antibacterial properties of chitosan, but also improves the dressing. mechanical properties

Method used

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  • A preparation method of cellulose and chitosan composite dressing containing mesoporous silica
  • A preparation method of cellulose and chitosan composite dressing containing mesoporous silica
  • A preparation method of cellulose and chitosan composite dressing containing mesoporous silica

Examples

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Effect test

Embodiment 1

[0047] A preparation method of a cellulose and chitosan composite dressing containing mesoporous silicon dioxide, the specific steps are as follows:

[0048] 1) Configure 0.5mol / L phosphate buffer solution (pH=6.0);

[0049] 2) Ultrasonic disperse the SBA-15 particles in the buffer solution prepared in step 1), soak for 48 hours to obtain a SBA-15 mesoporous silica / phosphate buffer solution dispersion with a mass fraction of 15%, and refrigerate to -5°C stand-by;

[0050] 3) Prepare a cellulose solvent (NaOH / urea aqueous solution, wherein the mass concentration of sodium hydroxide is 7%, and the mass concentration of urea is 12%), pre-cool to -12°C, then put in cellulose, stir to dissolve, and perform defoaming, Centrifuge to remove impurities to obtain a cellulose solution with a mass fraction of 4%, and pre-cool to -12°C to keep it warm;

[0051] 4) Add the pre-cooled mesoporous silica / buffer solution dispersion prepared in step 2) into the cellulose solution pre-cooled to...

Embodiment 2

[0058] A preparation method of a cellulose and chitosan composite dressing containing mesoporous silicon dioxide, the specific steps are as follows:

[0059] 1) Configure 0.2mol / L phosphate buffer solution (pH=6.0);

[0060] 2) Ultrasonic disperse the SBA-15 particles in the buffer solution prepared in step 1), soak for 24 hours to obtain a SBA-15 mesoporous silica / phosphate buffer solution dispersion with a mass fraction of 10%, and refrigerate to -3°C stand-by;

[0061] 3) Configure a cellulose solvent (NaOH / urea aqueous solution, wherein the mass concentration of sodium hydroxide is 6%, and the mass concentration of urea is 10%), pre-cool to -12°C, then put in cellulose, stir to dissolve, and perform defoaming, Centrifuge to remove impurities to obtain a cellulose solution with a mass fraction of 3.5%, and pre-cool to -12°C to keep it warm;

[0062] 4) Add the pre-cooled mesoporous silica / buffer solution dispersion prepared in step 2) into the cellulose solution pre-coole...

Embodiment 3

[0069] A preparation method of a cellulose and chitosan composite dressing containing mesoporous silicon dioxide, the specific steps are as follows:

[0070] 1) Configure 0.1mol / L citric acid-sodium citrate buffer solution (pH=6.4);

[0071] 2) Ultrasonic disperse the MCM-41 particles in the buffer solution prepared in step 1), soak for 72 hours to obtain a 5% MCM-41 mesoporous silica / citric acid-sodium citrate buffer solution dispersion, and refrigerate to -3°C for use;

[0072] 3) Configure a cellulose solvent (NaOH / urea aqueous solution, wherein the mass concentration of sodium hydroxide is 6%, and the mass concentration of urea is 12%), pre-cool to -12°C, then put in cellulose, stir to dissolve, and perform defoaming, Centrifuge to remove impurities to obtain a cellulose solution with a mass fraction of 4%, and pre-cool to -12°C to keep it warm;

[0073] 4) Add the pre-cooled mesoporous silica / buffer solution dispersion prepared in step 2) into the cellulose solution pre...

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Abstract

The invention relates to a preparation method of a cellulose and chitosan composite dressing containing mesoporous silica, comprising the following steps: 1) ultrasonically dispersing mesoporous silica particles in a buffer solution to obtain mesoporous silica / Buffer solution dispersion; 2) Prepare the cellulose solution; 3) Add the mesoporous silica / buffer solution dispersion into the cellulose solution, stir and mix well, pour it into the film forming template to form a film, and then solidify it in the solidification solution Then wash with water to obtain the mesoporous silica / cellulose blended membrane; 4) adopt the pressurized osmosis method to pass the chitosan solution through the mesoporous silica / cellulose blended membrane, wash and dry to obtain the mesoporous silica containing Silica-based cellulose and chitosan composite dressing. The dressing prepared by the method has good biocompatibility and biological activity, high tensile strength, porous structure, good air permeability and moisture retention, and long-term bactericidal and antibacterial effects.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials, and in particular relates to a preparation method of a cellulose and chitosan composite dressing containing mesoporous silicon dioxide. Background technique [0002] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. Along with the increase of diabetic patient and chronic ulcer disease, the market value of medical dressing also becomes more and more important. In the second half of the 19th century, the surgeon Gamgee invented the absorbent and antibacterial Gamgee dressing, a cotton pad. Since Dr. George Winter, a British scientist, discovered that a humid environment is beneficial to wound healing in 1962, and put forward the "moist wound healing theory", people have made breakthroughs in the understanding of the wou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/18A61L15/28A61L15/42A61L15/44A61L15/46
Inventor 喻发全沈陟蔡宁薛亚楠王建芝
Owner WUHAN INSTITUTE OF TECHNOLOGY