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Preparation method and application of a nano-chitin composite calcium alginate medical dressing

A nano-chitin and calcium alginate medical technology, applied in the field of biomedical materials, can solve the problems of difficult dressing and low cell adhesion, and achieve the effects of preventing wound infection, accelerating cell growth, and easy operation

Active Publication Date: 2020-06-23
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the single sodium alginate medical dressing has the disadvantage of low cell adhesion, and the dry calcium alginate sponge is brittle and not suitable for bending, and is not easy to bandage

Method used

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  • Preparation method and application of a nano-chitin composite calcium alginate medical dressing
  • Preparation method and application of a nano-chitin composite calcium alginate medical dressing
  • Preparation method and application of a nano-chitin composite calcium alginate medical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Take 10g 0.5wt% β-chitin nanofibers, add 0.0182g calcium carbonate, stir to disperse; add 0.2g sodium alginate powder and 0.05g glycerol, stir to dissolve; add 0.0647g gluconolactone, stir for 2 minutes, Pour into the mold. Stand for 24 hours, freeze-dry; cut, encapsulate, Co 60 Irradiation and sterilization are carried out to obtain the nano-chitin / calcium alginate medical dressing.

Embodiment 2

[0042] Take 10g 0.5wt% α-chitin nanowhiskers, add 0.0182g calcium carbonate, stir to disperse; add 0.2g sodium alginate powder and 0.05g glycerol, stir to dissolve; add 0.0647g gluconolactone, stir for 2 minutes , Pour into the mold. Stand for 24 hours, freeze-dry; cut, encapsulate, Co 60 Irradiation and sterilization are carried out to obtain the nano-chitin / calcium alginate medical dressing.

Embodiment 3

[0044] Take 10g of 0.25wt% β-chitin nanofibers, add 0.0182g of calcium carbonate, stir to disperse; add 0.2g of sodium alginate powder and 0.025g of glycerol, stir to dissolve; add 0.0647g of gluconolactone, stir for 2 minutes, Pour into the mold. Stand for 24 hours, freeze-dry; cut, encapsulate, Co 60 Irradiation and sterilization are carried out to obtain the nano-chitin / calcium alginate medical dressing.

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Abstract

The invention discloses a preparation method and application of a medial dressing compounding nano chitin and calcium alginate and relates to the field of biological medical materials. The preparationmethod includes: mixing the nano chitin obtained through TEMPO oxidation with sodium alginate, calcium carbonate and a softener according to different proportions, evenly stirring, adding a certain amount of glucolactone, stirring for several minutes, pouring into a mould, standing for several hours to achieve sufficient gelatinization, and performing freeze drying to obtain the sponge-like medical dressing. Compared with traditional gauze, the dressing has an evident wound healing promoting effect. The preparation method is simple in production process, controllable in processing, low in cost, nontoxic and suitable for large-scale production. The prepared medical dressing can be used as a biological medical material and is especially promising in application prospect in fields such as wound healing.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to a preparation method and application of a nano-chitin composite calcium alginate medical dressing. Background technique [0002] Hundreds of millions of people around the world need to undergo surgical operations every year, using medical dressings to wrap their wounds, acting as a temporary barrier to the wounds, preventing or controlling wound infections to protect the human body. At present, traditional single dressings such as gauze are still commonly used in surgical wounds, but traditional dressings have disadvantages such as poor antibacterial properties, poor absorption of exudate, and slow healing time. With the improvement of people's quality of life, surgical patients have correspondingly improved requirements for wound healing and comfort, and they hope to shorten the recovery time. Therefore, the development of new medical dressings that are conducive to wo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/734A61L15/42A61L15/62A61L15/18A61L15/20A61L15/28
CPCA61L15/18A61L15/20A61L15/28A61L15/42A61L15/425A61L15/62A61L2400/04A61L2400/12C08L5/08
Inventor 杜予民庞知益高慧敏钟自彪夏浩洋叶啟发
Owner WUHAN UNIV