Composition capable of blocking generation of nitrosamine and killing helicobacter pylori

A technology of Helicobacter pylori and composition, which is applied in the formulation field of health care products, and can solve the problems of carcinogenicity and cancer occurrence in animals or humans

Inactive Publication Date: 2015-10-07
WUXI HONGRUI BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Not only long-term small doses can cause cancer in animals or

Method used

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  • Composition capable of blocking generation of nitrosamine and killing helicobacter pylori
  • Composition capable of blocking generation of nitrosamine and killing helicobacter pylori
  • Composition capable of blocking generation of nitrosamine and killing helicobacter pylori

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Mix 60g of xylitol, 0.5g of orange essence, 0.1g of orange pigment, 10g of silicon dioxide, 10g of magnesium stearate and 19.6g of light calcium carbonate powder to form a 100g matrix.

[0026] Add 600 g of L-ascorbyl palmitate, 300 g of L-ascorbic acid and 50 g of cysteine ​​into the 50 g of the base, and stir while adding, so that they are uniformly mixed with the base. That is, 1000 g of this composition was obtained.

Embodiment 2

[0028] Get 6 stoppered test tubes of 50ml and number them, add 10.0ml concentration respectively to be the sodium nitrite solution of 200 μ g / ml, the citric acid-disodium hydrogen phosphate buffer solution of 10.0ml pH=3.0 and this composition 10.0mg (control group Add 10.0 mg of calcium carbonate powder to the test tube), then add deionized water to the mark, mix well, and place it in a constant temperature water bath at 37°C for 30 minutes.

[0029] The content of residual nitrite in the treated samples was determined according to the method of "Determination of Nitrite and Nitrate in Food GB 5009.33-2010 Second Method Spectrophotometry".

[0030] Experimental results show that the composition has a very good nitrite removal effect, and residual nitrite is no longer detected in samples treated with the composition.

Embodiment 3

[0032] Take six 50ml stoppered test tubes and number them, add 10.0ml sodium nitrite solution with a concentration of 1mmol / l, 10.0ml dimethylamine with a concentration of 1mmol / l, and 10.0ml citric acid-hydrogen phosphate with a pH=3.0 Sodium buffer solution and 10.0 mg of this composition (10.0 mg of calcium carbonate powder was added to the test tube of the control group), then add deionized water to the mark, mix thoroughly, and place in a constant temperature water bath at 37°C for 60 minutes.

[0033] Use a pipette gun to draw 10.0ml of the above solution into a 50ml beaker, add 0.5% Na 2 CO 3 Solution 5ml terminates above-mentioned reaction, then according to " the determination of N-nitrosamines in food GB 5009.26-2003 second method gas chromatography mass spectrometer method " method is measured the content of the N-nitrosodimethylamine in the processed sample content.

[0034] Experimental results show that the composition has a very good blocking effect on N-nitro...

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Abstract

The invention belongs to the technical field of health product formulas and specifically relates to a composition capable of blocking the generation of nitrosamine and killing helicobacter pylori. An oral health product capable of eliminating nitrites in food and blocking the generation of nitrosamine and having a good helicobacter pylori killing effect is provided. According to the composition, L-ascorbyl fatty acid ester is taken as the active ingredient for killing the helicobacter pylori, and L-ascorbic acid and amino acids are taken as the active ingredients for eliminating nitrites and blocking the generation of the nitrosamine; the stated health effect can be guaranteed, the nutrition can be enhanced and no any toxic and harmful risk exists; in short, the composition has a wide application prospect in the field of public health for preventing digestive system cancers, such as an esophagus cancer and a stomach cancer.

Description

technical field [0001] The invention belongs to the technical field of formulations of health products, in particular to a composition capable of blocking the generation of nitrosamines and killing Helicobacter pylori. Background technique [0002] In recent years, the incidence of cancer has shown an increasing trend, and has become an important cause of death for residents in our country, seriously endangering people's physical and mental health and the harmonious development of society. Among the carcinogenic factors that have been identified so far, the oral intake of carcinogens is one of the important factors, among which the intake of nitrosamines is the most concerned. [0003] The first is the breadth of existence. Nitrosamine compounds are formed by the action of nitrite and secondary amines in proteins. They are widely distributed in nature and are commonly found in grains, milk, cheese, tobacco and alcohol, bacon, barbecue, sea fish, canned food and In drinking...

Claims

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Application Information

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IPC IPC(8): A23L1/30A23L1/305
CPCA23V2002/00A23V2200/32A23V2200/308
Inventor 汤鲁宏汤宁冯玉舟
Owner WUXI HONGRUI BIOMEDICAL TECH CO LTD
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