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Preparation method of chitosan quaternary ammonium salt/collagen composite coating on the surface of medical metal implant

A chitosan quaternary ammonium salt and composite coating technology, applied in the direction of coating, prosthesis, medical science, etc., can solve the problems of decreased electric field responsiveness, limited coating control, limited improvement of bearing capacity, etc., and achieves wide application Foreground, release behavior controllable modulation, effect of increased ability

Active Publication Date: 2017-06-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, according to the deposition mechanism of mineralized collagen, a pH gradient will be generated near the substrate during the electrochemical deposition process, and chitosan will lose protons at a certain depth deposited to the coating as the pH increases, and the chitosan that loses protons responds to the electric field However, the property of chitosan decreased sharply, and the enrichment of chitosan in the inner or outer layer of the mineralized collagen coating could not be controlled, which limited the control of the coating on the bearing space of growth factors, and at the same time lost the chitosan and growth factors of protons. The Coulomb force between them drops sharply, which limits the improvement of the load-carrying capacity of the entire coating to growth factors, etc.

Method used

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  • Preparation method of chitosan quaternary ammonium salt/collagen composite coating on the surface of medical metal implant
  • Preparation method of chitosan quaternary ammonium salt/collagen composite coating on the surface of medical metal implant
  • Preparation method of chitosan quaternary ammonium salt/collagen composite coating on the surface of medical metal implant

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Embodiment 1

[0023] 1) quaternary ammonium root substitution degree is 98%, molecular mass is 30000 2-hydroxypropyltrimethylammonium chloride chitosan is dissolved in distilled water, preparation concentration is the chitosan quaternary ammonium salt aqueous solution of 0.5g / L, put Stand-by at 4°C; dissolve Beiling liquid type I collagen in 0.005mol / L acetic acid to prepare a collagen acetic acid solution with a concentration of 0.5g / L, and place it at 4°C for use;

[0024] 2) Preparation of electrolyte: Ca(NO 3 ) 2 ·6H 2 O is dissolved in water and prepared as Ca(NO 3 ) 2 aqueous solution, the NH 4 h 2 PO 4 Dissolved in water, prepared as NH with a phosphorus concentration of 80mmol / L 4 h 2 PO 4 aqueous solution, the Ca(NO 3 ) 2 Aqueous solution and NH 4 h 2 PO 4 The aqueous solution was stirred and mixed to obtain A solution. Mix Beiling liquid type I collagen, 2-hydroxypropyltrimethylammonium chloride chitosan solution with solution A to make the quaternary ammonium root ...

Embodiment 2

[0028] 1) quaternary ammonium root substitution degree is 98%, molecular mass is 30000 2-hydroxypropyltrimethylammonium chloride chitosan is dissolved in distilled water, preparation concentration is the chitosan quaternary ammonium salt aqueous solution of 0.5g / L, put Stand-by at 4°C; dissolve Beiling liquid type I collagen in 0.005mol / L acetic acid to prepare a collagen acetic acid solution with a concentration of 0.5g / L, and place it at 4°C for use;

[0029] 2) Preparation of electrolyte: Ca(NO 3 ) 2 ·6H 2 O is dissolved in water and prepared as Ca(NO 3 ) 2 aqueous solution, the NH 4 h 2 PO4 Dissolved in water, prepared as NH with a phosphorus concentration of 80mmol / L 4 h 2 PO 4 aqueous solution, the Ca(NO 3 ) 2 Aqueous solution and NH 4 h 2 PO 4 The aqueous solution was stirred and mixed to obtain A solution. Mix Beiling liquid type I collagen, 2-hydroxypropyltrimethylammonium chloride chitosan solution with solution A to make the quaternary ammonium root an...

Embodiment 3

[0033] 1) quaternary ammonium root substitution degree is 98%, molecular mass is 30000 2-hydroxypropyltrimethylammonium chloride chitosan is dissolved in distilled water, preparation concentration is the chitosan quaternary ammonium salt aqueous solution of 0.5g / L, put Stand-by at 4°C; dissolve Beiling liquid type I collagen in 0.005mol / L acetic acid to prepare a collagen acetic acid solution with a concentration of 0.5g / L, and place it at 4°C for use;

[0034] 2) Preparation of electrolyte: Ca(NO 3 ) 2 ·6H 2 O is dissolved in water and prepared as Ca(NO 3 ) 2 aqueous solution, the NH 4 h 2 PO 4 Dissolved in water, prepared as NH with a phosphorus concentration of 80mmol / L 4 h 2 PO 4 aqueous solution, the Ca(NO 3 ) 2 Aqueous solution and NH 4 h 2 PO 4 The aqueous solution was stirred and mixed to obtain A solution. Mix Beiling liquid type I collagen, 2-hydroxypropyltrimethylammonium chloride chitosan solution with solution A to make the quaternary ammonium root ...

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Abstract

The preparation method of the chitosan quaternary ammonium salt / collagen composite coating on the surface of a medical metal implant disclosed by the invention comprises preparing an electrolyte solution containing calcium, phosphorus, collagen and chitosan quaternary ammonium salt, and using a platinum sheet as a counter electrode , using the acid-cleaned metal substrate as the working electrode, using the multi-potential step mode for electrochemical deposition, by adjusting the positive and negative of the working electrode potential, the size of each step, and the deposition time of each step, without multiple depositions, it can be quickly and easily The controllable spatial distribution of the chitosan quaternary ammonium salt in the mineralized collagen coating on the surface of the substrate is realized, that is, the inner layer of the collagen coating is enriched with the chitosan quaternary ammonium salt and the outer layer of the coating is enriched with the chitosan quaternary ammonium salt. Utilizing the positively charged nature of chitosan quaternary ammonium salt, the biological growth factors are carried on different spatial positions of the collagen coating, which realizes the controllable regulation of the release behavior of biological growth factors, and at the same time increases the ability of the coating to carry biological growth factors , has broad application prospects in the field of hard bone tissue repair.

Description

technical field [0001] The invention relates to a method for preparing a surface coating of a medical metal implant, in particular to a method for preparing a mineralized collagen coating on the surface of a medical metal implant. Background technique [0002] In the process of bone repair, the body's own cells produce different growth factors at different stages to regulate the smooth progress of osseointegration, and the release behavior of growth factors often determines the success of bone repair. Therefore, for new metal implant materials, it should not only have good biocompatibility, but also have good growth factor or drug loading capacity and controllable release behavior of the growth factors it carries. Usually, a layer of organic substances with slow-release function is coated on the surface of metal implants and growth factor agents are embedded to meet the requirements of biocompatibility, growth and bearing capacity, and release behavior control. However, coa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/54C25D9/02C25D5/00
Inventor 翁文剑陈潞程逵王慧明林军
Owner ZHEJIANG UNIV
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