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Application of ERK inhibitor PD98059 in preparation of medicine for treatment of alveolar hydatid disease

A PD98059, 5. PD98059 technology, applied in the field of medicinal chemistry, can solve the problems of poor gastrointestinal absorption, low solubility, and unsatisfactory clinical application.

Inactive Publication Date: 2015-11-04
姜玉峰
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] In the field, albendazole is tried to treat hepatic alveolar echinococcosis, but its clinical application is not ideal because of its low solubility, poor gastrointestinal absorption and wide systemic distribution.
Although the development and application of new drugs and dosage forms are continuously carried out, and the therapeutic effects of drugs have also been improved, the clinical application is still not ideal due to many serious side effects, especially for drugs that inhibit the infiltration and metastatic growth of alveolar echinococcosis study less

Method used

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  • Application of ERK inhibitor PD98059 in preparation of medicine for treatment of alveolar hydatid disease
  • Application of ERK inhibitor PD98059 in preparation of medicine for treatment of alveolar hydatid disease
  • Application of ERK inhibitor PD98059 in preparation of medicine for treatment of alveolar hydatid disease

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Embodiment Construction

[0020] In order to illustrate the application effect of PD98059, the applicant conducted an in vitro experiment to illustrate the killing effect of PD98059 on Echinococcus alveolar protoscole.

[0021] Experiment 1: The effect of PD98059 on the protoscole of alveolar Echinococcus in vitro

[0022] The gerbils inoculated with alveolar Echinococcus protoscole for 4-6 months were killed by neck dissection after anesthesia, dissected under sterile conditions, and the complete alveolar Echinococcus tissue pieces were taken out and placed in an inverted Put an appropriate amount of PBS (PH=7.2) in a sterile dressing-changing bowl, move the dressing-changing bowl to the ultra-clean bench, remove the host tissue on the surface of the tissue block, wash the alveolar Echinococcus tissue block with PBS 3-5 times, and then Grind with a homogenizer, filter with a sieve, collect the filtrate in a sterile centrifuge tube, let it stand for 5 minutes, discard the supernatant, wash the protosco...

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Abstract

The present invention discloses application of ERK inhibitor PD98059 in preparation of a medicine for treatment of alveolar hydatid diseasein, and the ERK inhibitor PD98059 is used for killing alveolar hydatid diseasein pathogen-bubble hydatid tapeworm, has significant hydatid protoscolex inhibition and killing effect, and can be used for treatment of alveolar hydatid disease.

Description

technical field [0001] The invention relates to the pharmaceutical application of PD98059 and belongs to the field of medicinal chemistry. Background technique [0002] Alveolar echinococcosis (alveolar echinococcosis, AE) is caused by the tapeworm larvae of the echinococcosis tapeworm parasitizing in humans and other animals, which can cause serious harm to human health and the development of animal husbandry. A zoonotic parasitic disease. Although the incidence of alveolar echinococcosis is only 2% to 3% of that of cystic echinococcosis, its harm is far more than that of cystic echinococcosis. In my country, alveolar echinococcosis is mainly distributed in northwest and southwest areas with developed agriculture and animal husbandry and economically underdeveloped areas. The prevalence rate of the population is 0.3% to 4.8%, and it may be 10% in some areas. The currently recognized effective treatment for hepatic alveolar echinococcosis is radical hepatectomy, but the on...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P33/00
Inventor 姜玉峰吕海龙雷颖
Owner 姜玉峰
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