Preparation method and application of nitrofuran molecularly imprinted polymer microspheres

A technology of molecular imprinting and nitrofuran, applied in the field of medicine, can solve the problems of only one substance adsorbed, irregular particles of molecularly imprinted polymer, etc., and achieve the effect of uniform size, regular particle shape and improved adsorption.

Active Publication Date: 2018-02-09
SHENZHEN SINO ASSESSMENT GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for preparing nitrofuran molecularly imprinted polymer microspheres, which solves the problem that the molecularly imprinted polymer particles obtained by the existing method are irregular and can only adsorb one substance

Method used

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  • Preparation method and application of nitrofuran molecularly imprinted polymer microspheres
  • Preparation method and application of nitrofuran molecularly imprinted polymer microspheres
  • Preparation method and application of nitrofuran molecularly imprinted polymer microspheres

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preparation example Construction

[0021] The preparation method of nitrofuran molecularly imprinted polymer microspheres adopts a sacrificial silica gel method to synthesize nitrofuran molecularly imprinted polymer microspheres. Specifically follow the steps below;

[0022] Step 1. According to the molar ratio of α-methacrylic acid:furaltadone and nitrofurazone molecules=6:1~8:1, dissolve in the solvent, ultrasonically assist the dissolution, then add a crosslinking agent, fill with argon, seal, Prepolymerize in the refrigerator for 16h to 22h, then transfer the prepolymer to a PP plastic column polymerization reactor, add column chromatography silica gel, the ratio of the mass of column chromatography silica gel to the template molecule is 1.2g:1mmol~ 2g: 1mmol and initiator, shake fully, fill with argon again to exhaust oxygen, and then seal;

[0023] Step 2. React the sealed mixture in a constant temperature water bath shaker at 60°C to 70°C for 20h to 24h, cool it down, put the mixture in the refrigerator...

Embodiment 1

[0031] Dissolve а-methacrylic acid, furaltadone and nitrofurazone in acetonitrile solvent at a molar ratio of 7:1, the volume ratio of furaltadone and nitrofurazone to acetonitrile is 1mmol:80mL, and then the power is 65W Ultrasound for 5min under the condition of ethylene glycol dimethacrylate, and the molar ratio of ethylene glycol dimethacrylate:furaltadone and nitrofurazone is 45:1; fill with argon gas to remove oxygen, and then seal, Prepolymerize in the refrigerator for 20 hours, then transfer the prepolymer to a PP plastic column polymerization reactor, then add azobisisobutyronitrile and column chromatography silica gel, the mass of column chromatography silica gel and the ratio of template molecules Be 1.5g: 1mmol, the amount of the substance of α-methacrylic acid and ethylene glycol dimethacrylate: the mass ratio of azobisisobutyronitrile is 135mmol: 1g; Charge into argon, seal; After sealing The mixture was reacted in a constant temperature water bath shaker at 65°C...

Embodiment 2

[0044] According to the molar ratio α-methacrylic acid: the ratio of furaltadone and nitrofurazone molecule=6:1 is dissolved in acetonitrile, the volume ratio of the amount of furaltadone and nitrofurazone to acetonitrile is 1mmol:70mL; Add ethylene glycol dimethacrylate again, and the molar ratio of ethylene glycol dimethacrylate: furaltadone and nitrofurazone is 40:1; fill with argon, seal, pre-polymerize in refrigerator for 16h, and then pre-polymerize The polymer is transferred to a PP plastic columnar polymerization reactor, and column chromatography silica gel and azobisisobutyronitrile are added. The quality of the column chromatography silica gel and the ratio of template molecules are 1.2g:1mmol, а-methacrylic acid The amount of substance and ethylene glycol dimethacrylate: the mass ratio of azobisisobutyronitrile is 130mmol: 1g; shake fully, fill with argon again to exhaust oxygen, and then seal; seal the sealed mixture at 60°C React in a constant temperature water b...

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Abstract

The invention discloses a preparation method of nitrofuran molecularly imprinted polymer microspheres. а-methacrylic acid, furaltadone and nitrofurazone molecules are dissolved in a solvent, a crosslinking agent is added, argon gas is filled, prepolymerized, and then transferred To the PP plastic column polymerization reactor, add column chromatography silica gel and initiator, oscillate, and fill with argon again; react in a constant temperature water bath shaker, put it in a refrigerator, add excess hydrofluoric acid, and Stir, filter, wash twice with deionized water and methanol, and dry; use a solution of acetic acid and methanol with a volume ratio of 1:9 to 1:7 for Soxhlet extraction, wash the residual acetic acid with methanol, and then dry to a constant weight to obtain nitrofuran molecularly imprinted polymer microspheres. The prepared nitrofuran-based molecularly imprinted polymer microspheres are used as fillers for SPE columns to detect trace amounts of furazolidone, furaltadone, nitrofurazone and nitrofurantoin.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a preparation method of nitrofuran molecularly imprinted polymer microspheres, and also relates to the application of the nitrofuran molecularly imprinted polymer microspheres. Background technique [0002] Nitrofuran drugs are an important class of anti-infective drugs. They are synthetic broad-spectrum antibacterial drugs with the basic structure of 5-nitrofuran. Furazolidone (FZD), Nitrofurazone (NFZ), and furazolidone are commonly used. Ketones (Furaltadone, FTD) and Nitrofurantoin (Nitrofurantion, NFT). They are widely used in feed additives and therapeutic drugs as broad-spectrum antibiotics. Studies have shown that nitrofuran drugs and their metabolites are highly toxic, have teratogenic side effects, and can induce cancer. Therefore, since 1995, they have been gradually included in the banned list in countries all over the world. In recent years, some progress has been ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/08
Inventor 曹维强陈孝建饶远旋陈鹏飞胡仕屏范明志
Owner SHENZHEN SINO ASSESSMENT GRP
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